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Endocrine Pathology

, Volume 30, Issue 1, pp 1–7 | Cite as

Increased Expression of GARP in Papillary Thyroid Carcinoma

  • Xiaoxu Zhang
  • Miao Guo
  • Jing Yang
  • Yuxiao Zheng
  • Yanjie Xiao
  • Wei LiuEmail author
  • Fu RenEmail author
Article

Abstract

Regulatory T cells (Tregs) are immunosuppressive immune cells that play an important role in tumor development. Suppression of Treg function is considered to be an effective strategy for cancer therapy. Glycoprotein A repetitions predominant (GARP) has been found on the surface of activated Tregs. GARP has been recently observed in only a few solid tumors including breast, colon, lung cancers, and melanoma. However, its function in cancers remains unknown. Here, we investigated the expression of GARP in human papillary thyroid carcinoma (PTC) and its prognostic significance. In this study, immunohistochemistry was performed to examine the expression of GARP and Foxp3 in 19 human PTC tissues (including 10 cases with and 9 cases without lymph node metastasis) and 20 benign thyroid diseases (including 10 cases with nodular goiter and 10 cases with adenoma). Compared with benign thyroid diseases, we found a significant increase in the expression of GARP in PTC. Increased GARP expression in PTC was positively correlated with increased expression of Foxp3, which is very important for development of Tregs. But, there is no significant association of elevated expression of GARP with lymph node metastasis in PTC. Our results indicate that GARP is implicated in the development of PTC and might be a potential novel target for anticancer therapy. In addition, our findings further support the existence of a positive-feedback loop between GARP and Foxp3.

Keywords

GARP Foxp3 Papillary thyroid carcinoma Thyroid Cancer 

Notes

Acknowledgements

The authors thank Dr. Fengjie Qi for her confirmation of the pathological diagnosis of the patients. This study was supported by the high talent support program project of Jinzhou Medical University (2015RC011).

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

The study was approved by the Ethics Committee of Jinzhou Medical University.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of AnatomyCollege of Basic Medical Sciences of Jinzhou Medical UniversityJinzhouChina
  2. 2.Department of Clinical LaboratoryThe First Affiliated Hospital of Jinzhou Medical UniversityJinzhouChina
  3. 3.Department of PathologyCollege of Basic Medical Sciences of Jinzhou Medical UniversityJinzhouChina
  4. 4.Department of Medical ImagingJinzhou Medical UniversityJinzhouChina
  5. 5.Department of EpidemiologyPublic Health College of Jinzhou Medical UniversityJinzhouChina
  6. 6.Institute of Biological AnthropologyJinzhou Medical UniversityJinzhouChina
  7. 7.Liaoning Province Key Laboratory of Chinese Physical Characteristics Research (LPKL-CPCR)JinzhouChina

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