Endocrine Pathology

, Volume 29, Issue 3, pp 231–235 | Cite as

Reclassification as NIFTP: a Retrospective Review in a Single Institution with an Emphasis on Workload

  • Kevin O’Hare
  • E. O’Regan
  • A. Khattak
  • M. L. Healy
  • M. Toner


The aim of this study was to determine the number of cases of papillary thyroid carcinoma (PTC) which could be reclassified as non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) in our institute over a 10-year period, document their clinical status and assess the number of slides that had to be reviewed per case to exclude NIFTP. The histopathology reports for thyroid resections for all papillary carcinoma over a 10-year period (2007–2016) were reviewed. Five hundred forty-five histopathology reports were reviewed, and 71 cases were identified as potential cases of NIFTP. Forty-nine (69%) cases had been referred from external departments and the slides were not available for review. Of the remaining 22 (31% of 71) cases, 5 were reclassified as NIFTP. The 17 cases that were not reclassified as NIFTP required review of 114 of 356 slides (median 5.5 slides per case) was required to exclude NIFTP. For the 5 NIFTP cases, 58 slides were reviewed (median 12 slides per case). We found that review of the histology reports alone was adequate for exclusion in most cases, e.g. classic PTC or EVPTC cases with documented lymphovascular invasion or capsular invasion. As a single exclusion criterion is required for exclusion from reclassification as NIFTP, this can be achieved efficiently. Two of the five patients received radioactive iodine [RAI] as per standard treatment at time of diagnosis, on the basis of tumour size. None have recurrent or metastatic disease with mean follow-up of 5.8 years.


Thyroid neoplasms Thyroid cancer Papillary carcinoma Papillary follicular/pathology Reclassification Follow-up 


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

“For this type of study, formal consent is not required. This article does not contain any studies with human participants or animals performed by any of the authors.


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of HistopathologySt. James HospitalDublinIreland
  2. 2.Department of Oral and Maxillofacial Surgery, Medicine and PathologyDublin Dental University HospitalDublinIreland
  3. 3.Department of EndocrinologySt. James HospitalDublinIreland

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