Endocrine Pathology

, Volume 24, Issue 3, pp 167–168 | Cite as

Macrofollicular Variant of Follicular Thyroid Carcinoma: A Case Report

  • Claudio De Vito
  • Massimo Bongiovanni
  • Frederic Triponez
  • Marc PusztaszeriEmail author

Case Report

A 37-year-old female known for systemic lupus erythematosus underwent a right thyroid lobectomy for a growing nodule in the right lobe. A fine-needle aspiration biopsy (FNAB) performed 4 years before surgery reported a microfollicular proliferation. A second FNAB performed a few months before surgery revealed a benign lesion. The surgical specimen was fixed in 4 % buffered formaldehyde. The entire nodule was sampled, with particular attention to the capsule, and embedded in paraffin and corresponding sections were stained with hematoxylin and eosin for histological examination. Immunohistochemistry using HBME1 and galectin-3 was performed.

What is Your Diagnosis?

The pathological diagnosis of the patient was follicular thyroid carcinoma, macrofollicular variant, which is minimally invasive, stage pT2 pNX.

On gross section, the nodule measured 4 × 4 × 3.5 cm. It was encapsulated with a shiny colloidal appearance without calcification (Fig.  1a). On histology, the nodule was...


Systemic Lupus Erythematosus Papillary Thyroid Carcinoma Thyroid Nodule Follicular Thyroid Carcinoma Follicular Adenoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Rosai JCM, DeLellis R: Atlas of Tumor Pathology: Tumors of the Thyroid Gland, series 3. Washington, Armed Forces Institute of Pathology, 1992.Google Scholar
  2. 2.
    Albores-Saavedra J, Housini I, Vuitch F, Snyder WH 3rd. Macrofollicular variant of papillary thyroid carcinoma with minor insular component. Cancer 80:1110–1116, 1997.PubMedCrossRefGoogle Scholar
  3. 3.
    Bongiovanni M, Gremaud M, Moulin CS, Scheidegger C, Biton C, Clément S. Macrofollicular variant of follicular thyroid carcinoma: a clinical, cytologic, morphologic, and image analysis study of a unique case. Ann Diagn Pathol. 13:101–105, 2009.PubMedCrossRefGoogle Scholar
  4. 4.
    Cibas ES, Ali SZ. The Bethesda System For Reporting Thyroid Cytopathology. Am J Clin Pathol. 132:658–665, 2009.PubMedCrossRefGoogle Scholar
  5. 5.
    Maruta J, Hashimoto H, Suehisa Y, Yamashita H, Noguchi S, Aratake Y, Ohno E, Kobayashi TK. Improving the diagnostic accuracy of thyroid follicular neoplasms: cytological features in fine-needle aspiration cytology. Diagn Cytopathol. 39:28–34, 2011.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Claudio De Vito
    • 1
  • Massimo Bongiovanni
    • 2
  • Frederic Triponez
    • 3
  • Marc Pusztaszeri
    • 1
    Email author
  1. 1.Department of Clinical PathologyGeneva University HospitalGeneva 14Switzerland
  2. 2.Institute of PathologyLocarnoSwitzerland
  3. 3.Department of Thoracic and Endocrine SurgeryGeneva University HospitalGenevaSwitzerland

Personalised recommendations