Endocrine Pathology

, Volume 24, Issue 2, pp 110–113 | Cite as

Combined Large Cell Neuroendocrine Carcinoma and Adenocarcinoma of the Gallbladder

  • Nabeel Al-BrahimEmail author
  • Raeda Albannai

Clinical History

A 45-year-old male patient presented with right upper abdominal pain associated with anorexia, nausea, and passing of dark urine, a clinical picture of obstructive jaundice for 10 days. Laboratory tests revealed elevated liver enzymes as follows: alkaline phosphatase, 409 U/L (normal, 53–128); alanine transaminase, 356 U/L (normal, 10–60); aspartate aminotransferase, 166 U/L (normal, 10–40); total bilirubin, 136.5 μmol/L (normal, 3–20); and direct bilirubin, 94 mmol/L (normal 0–5). The patient underwent abdominal ultrasound and computerized tomography scan that revealed thickening of the gallbladder wall with multiple stones. In addition, there was a lobulated, “space-occupying lesion” in the liver at segment V. The mass extended to and was contiguous with the thickened fundus of the gallbladder. The entire mass (that involved the gallbladder and the liver) was 5.7 × 5.5 × 5.1 cm in size. The intra- and extrahepatic biliary radicals were dilated. Multiple enlarged...


Gall Bladder Neuroendocrine Tumor Carcinoid Tumor Obstructive Jaundice Small Cell Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Klimstra D, Modlin I, Coppola D, Lloyd R, Suster S. The pathologic classification of neuroendocrine tumors a review of nomenclature, grading, and staging systems. Pancreas 2010;39:707–712PubMedCrossRefGoogle Scholar
  2. 2.
    Hao H, Itoyama M, Tsubamoto H, Tsujimoto M, Hirota S. Large cell neuroendocrine carcinoma of the cervix associated with intestinal variant invasive mucinous adenocarcinoma. Pathol Int 2011;62:55–57.CrossRefGoogle Scholar
  3. 3.
    Akamatsu S, Kanamaru S, Ishihara M, Sano T, Soeda A, Hashimoto K. Primary large cell neuroendocrine carcinoma of the urinary bladder. Int J Urol 2008;15:1080–1083PubMedCrossRefGoogle Scholar
  4. 4.
    Deodhar KK, Kerkar RA, Suryawanshi P, Menon H, Menon S. Large cell neuroendocrine carcinoma of the endometrium: an extremely uncommon diagnosis, but worth the efforts. J Cancer Res Ther. 2011;7:211–213PubMedCrossRefGoogle Scholar
  5. 5.
    Pappotti M, Cassoni p, Sapino A, Passarino G, Krueger J, albores-Saavedra J. Large cell neuroendocrine carcinoma of the gallbladder: report of two cases. Am J Surg Pathol 2000;24:1424–1428CrossRefGoogle Scholar
  6. 6.
    Jun SR, Lee LM, Han JK, Choi BI. High-grade neuroendocrine carcinomas of the gallbladder and bile duct. Report of four cases with pathological correlation. J Comput Assit Tomogr 2006;30:604–609CrossRefGoogle Scholar
  7. 7.
    Noske A, Pahl S. Combined adenosquamous and large-cell neuroendocrine carcinoma of the gallbladder. Virch Arch 2006;449:135–136CrossRefGoogle Scholar
  8. 8.
    Oshiro H, Matsuo K, Mawatari H, et al. Mucin-producing gallbladder adenocarcinoma with focal small cell and large cell neuroendocrine differentiation associated with pancreaticobiliary maljunction. Pathol Intern 2008;58:780–786CrossRefGoogle Scholar
  9. 9.
    Sato K, Imai T, Shirota Y, Ueda Y, Katsuda S. Combined large cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder. Pathol Res Pract 2010;206:397–400PubMedCrossRefGoogle Scholar
  10. 10.
    Paniz Mondolfi AE, Slova D, Fan W, Attiyeh FF, Afthinos J, Reidy J, Pang Y, Theise ND. Mixed adenoneuroendocrine carcinoma (MANEC) of the gallbladder: a possible stem cell tumor? Pathol Int 2011;61:608–614PubMedCrossRefGoogle Scholar
  11. 11.
    Turner R, Lozoya O, Wang Y et al. Human hepatic stem cell and maturational liver lineage biology. Hepatology 2011;53:1035–1045.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  1. 1.Department of PathologyFarwaniya HospitalKuwait CityKuwait
  2. 2.SalmiyaKuwait

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