Endocrine Pathology

, Volume 23, Issue 2, pp 115–122 | Cite as

Occult Primary Medullary Thyroid Carcinoma Presenting with Pituitary and Parotid Metastases: Case Report and Review of the Literature

  • Andrea Conway
  • Andres Wiernik
  • Ajay Rawal
  • Cornelius Lam
  • Hector Mesa


Medullary thyroid carcinoma (MTC) accounts for <10% of all thyroid malignancies and is derived from the calcitonin-producing C cell [1, 2]. It is of particular interest because of its association with hereditary syndromes, aggressiveness, and refractoriness to adjuvant therapies, and its association with mutations in the RET (rearranged during transfection) proto-oncogene, which encodes a receptor tyrosine kinase that may be amenable to therapy with the recently available tyrosine kinase inhibitors (TKI) [3, 4]. Thyroid tumors metastasizing to the pituitary and parotid gland are rare, and medullary thyroid carcinoma metastatic to either site has only been reported in a handful of instances. Here, we report a rare case of an occult MTC, which presented with clinical symptoms associated with synchronous metastases to the pituitary and parotid gland, and discuss its differential diagnosis.

Case Report

A 61-year-old man with no significant past medical problems presented to...


Pituitary Adenoma Parotid Gland Diabetes Insipidus Medullary Thyroid Carcinoma Vandetanib 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC (outside the USA) 2012

Authors and Affiliations

  • Andrea Conway
    • 1
  • Andres Wiernik
    • 2
  • Ajay Rawal
    • 3
  • Cornelius Lam
    • 4
  • Hector Mesa
    • 3
  1. 1.Department of PathologyUniversity of MinnesotaMinneapolisUSA
  2. 2.Hematology-Oncology SectionUniversity of MinnesotaMinneapolisUSA
  3. 3.Department of PathologyVeterans Administration Health Care SystemMinneapolisUSA
  4. 4.Department of NeurosurgeryUniversity of MinnesotaMinneapolisUSA

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