Endocrine Pathology

, Volume 22, Issue 3, pp 126–133

Molecular Analysis of Thyroid Tumors

Article

DOI: 10.1007/s12022-011-9170-y

Cite this article as:
Bhaijee, F. & Nikiforov, Y.E. Endocr Pathol (2011) 22: 126. doi:10.1007/s12022-011-9170-y

Abstract

Thyroid cancer is the most common endocrine malignancy, and its incidence is rising in the USA and other countries. Papillary and follicular thyroid carcinomas are the two most common types of thyroid cancer. Non-overlapping genetic alterations, including BRAF and RAS point mutations, and RET/PTC and PAX8/PPARγ rearrangements, are found in more than 70% of papillary and follicular thyroid carcinomas. These represent the most common genetic alterations in thyroid cancer, as well as molecular markers of diagnostic and prognostic significance. The use of these and other emerging molecular markers will likely improve the diagnosis of malignancy in thyroid nodules as well as facilitate more individualized operative and postoperative management. Herein, we provide a brief overview of the common genetic alterations in papillary and follicular thyroid carcinoma and discuss the diagnostic and prognostic significance thereof.

Keywords

Thyroid cancer Papillary carcinoma Follicular carcinoma Mutations Genetic Molecular BRAF RET/PTC RAS PAX8/PPARγ 

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of PathologyUniversity of Mississippi Medical CenterJacksonUSA
  2. 2.Department of Pathology and Laboratory MedicineUniversity of Pittsburgh Medical CenterPittsburghUSA
  3. 3.Department of PathologyUniversity of Pittsburgh, UPMC PresbyterianPittsburghUSA

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