Endocrine Pathology

, Volume 19, Issue 1, pp 1–8

Hyalinizing Trabecular Tumor of the Thyroid: An Update


DOI: 10.1007/s12022-007-9002-2

Cite this article as:
Nosé, V., Volante, M. & Papotti, M. Endocr Pathol (2008) 19: 1. doi:10.1007/s12022-007-9002-2


Hyalinizing trabecular tumor (HTT) is a rare thyroid tumor of follicular cell origin with a trabecular pattern of growth and marked intratrabecular hyalinization. This tumor is known to share morphological and architectural similarities with paraganglioma and medullary thyroid carcinoma, as well as the nuclear features and RET/PTC1 translocations of papillary thyroid carcinoma. These tumors are not associated with RAS or BRAF mutations. Whether the presence of RET alterations in HTT are sufficient molecular proof of its relationship with papillary thyroid carcinoma (PTC) is still to be defined. Of great interest is the characteristic strong peripheral cytoplasmic and membranous staining of the tumor cells with MIB1 immunostain, not seen in any other thyroid neoplasm. Although cases of malignant HTT have been recorded, HTT should be considered a benign neoplasm or, at most, a neoplasm of extremely low malignant potential.


hyalinizing trabecular tumor hyalinizing trabecular adenoma thyroid papillary carcinoma BRAF RET/PTC 

Copyright information

© Humana Press Inc. 2007

Authors and Affiliations

  1. 1.Department of PathologyBrigham and Women’s Hospital, Harvard Medical SchoolBostonUSA
  2. 2.Department of Clinical and Biological SciencesUniversity of Turin and San Luigi HospitalTurinItaly
  3. 3.Department of PathologyBrigham and Women’s HospitalBostonUSA

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