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An Uncertainty Visual Analytics Framework for fMRI Functional Connectivity

  • Michael de Ridder
  • Karsten Klein
  • Jean Yang
  • Pengyi Yang
  • Jim Lagopoulos
  • Ian Hickie
  • Max Bennett
  • Jinman Kim
Original Article
  • 58 Downloads

Abstract

Analysis and interpretation of functional magnetic resonance imaging (fMRI) has been used to characterise many neuronal diseases, such as schizophrenia, bipolar disorder and Alzheimer’s disease. Functional connectivity networks (FCNs) are widely used because they greatly reduce the amount of data that needs to be interpreted and they provide a common network structure that can be directly compared. However, FCNs contain a range of data uncertainties stemming from inherent limitations, e.g. during acquisition, as well as the loss of voxel-level data, and the use of thresholding in data abstraction. Additionally, human uncertainties arise during interpretation due to the complexity in understanding the data. While existing FCN visual analytics tools have begun to mitigate the human ambiguities, reducing the impact of data limitations is an open problem. In this paper, we propose a novel visual analytics framework with three linked, purpose-designed components to evoke deeper interpretation of the fMRI data: (i) an enhanced FCN abstraction; (ii) a temporal signal viewer; and (iii) the anatomical context. Each component has been specifically designed with novel visual cues and interaction to expose the impact of uncertainties on the data. We augment this with two methods designed for comparing subjects, by using a small multiples and a marker approach. We demonstrate the enhancements enabled by our framework on three case studies of common research scenarios, using clinical schizophrenia data, which highlight the value in interpreting fMRI FCN data with an awareness of the uncertainties. Finally, we discuss our framework in the context of fMRI visual analytics and the extensibility of our approach.

Keywords

Visual Analytics Functional Magnetic Resonance Imaging Functional Connectivity Uncertainty Framework Visualization 

Notes

Compliance with Ethical Standards

Conflict of Interest

None declared.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Biomedical and Multimedia Information Technologies (BMIT) research groupThe University of SydneySydneyAustralia
  2. 2.Department of Computer Science and Information ScienceThe University of KonstanzKonstanzGermany
  3. 3.School of Mathematics and StatisticsThe University of SydneySydneyAustralia
  4. 4.Brain and Mind CentreThe University of SydneySydneyAustralia

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