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Towards Differential Connectomics with NeuroVIISAS

  • Sebastian Schwanke
  • Jörg Jenssen
  • Peter Eipert
  • Oliver Schmitt
Software Original Article

Abstract

The comparison of connectomes is an essential step to identify changes in structural and functional neuronal networks. However, the connectomes themselves as well as the comparisons of connectomes could be manifold. In most applications, comparisons of connectomes are applied to specific sets of data. In many studies collections of scripts are applied optimized for certain species (non-generic approaches) or diseases (control versus disease group connectomes). These collections of scripts have a limited functionality which do not support functional and topographic mappings of connectomes (hemispherical asymmetries, peripheral nervous system). The platform-independent and generic neuroVIISAS framework is built to circumvent limitations that come with variants of nomenclatures, connectivity lists and connectional hierarchies as well as restrictions to structural connectome analyses. A new analytical module is introduced into the framework to compare different types of connectomes and different representations of the same connectome within a unique software environment. As an example a differential analysis of the partial connectome of the laboratory rat that is based on virus tract tracing with the same regions of non-virus tract tracing has been performed. A relatively large connectional coherence between the two different techniques was found. However, some detected connections are described by virus tract-tracing only.

Keywords

Connectome Differential connectomics Neuronal networks Multidimensional connectomes Visualization Graph analysis Rat Nervous system 

Notes

Acknowledgements

We would like to thank Heidi Schumann and Christian Tominski (Computer Graphics, Institute of Computer Science, University of Rostock) for their helpful advice on the manuscript.

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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of AnatomyUniversity of RostockRostockGermany

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