, Volume 12, Issue 3, pp 365–379 | Cite as

Intensity Based Methods for Brain MRI Longitudinal Registration. A Study on Multiple Sclerosis Patients

  • Yago Diez
  • Arnau Oliver
  • Mariano Cabezas
  • Sergi Valverde
  • Robert Martí
  • Joan Carles Vilanova
  • Lluís Ramió-Torrentà
  • Àlex Rovira
  • Xavier Lladó
Original Article


Registration is a key step in many automatic brain Magnetic Resonance Imaging (MRI) applications. In this work we focus on longitudinal registration of brain MRI for Multiple Sclerosis (MS) patients. First of all, we analyze the effect that MS lesions have on registration by synthetically eliminating some of the lesions. Our results show how a widely used method for longitudinal registration such as rigid registration is practically unconcerned by the presence of MS lesions while several non-rigid registration methods produce outputs that are significantly different. We then focus on assessing which is the best registration method for longitudinal MRI images of MS patients. In order to analyze the results obtained for all studied criteria, we use both descriptive statistics and statistical inference: one way ANOVA, pairwise t-tests and permutation tests.


Brain MRI Longitudinal analysis Multiple sclerosis Registration 



We would like to thank to all the authors that have provided public registration algorithms. Moreover, we would like to specially thank the collaborators from University College London that provided us with the MS lesion filling software. This work has been supported by the Instituto de Salud Carlos III Grant PI09/91018, Grant VALTEC09-1-0025 from the Generalitat de Catalunya, and Grant CEM-Cat 2011 from the Fundació Esclerosi Múltiple. S. Valverde holds a FI-DGR2013 Grant from the Generalitat de Catalunya.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Yago Diez
    • 1
  • Arnau Oliver
    • 1
  • Mariano Cabezas
    • 1
  • Sergi Valverde
    • 1
  • Robert Martí
    • 1
  • Joan Carles Vilanova
    • 2
  • Lluís Ramió-Torrentà
    • 3
  • Àlex Rovira
    • 4
  • Xavier Lladó
    • 1
  1. 1.Computer Vision and Robotics GroupUniversity of GironaGironaSpain
  2. 2.Girona Magnetic Resonance CenterGironaSpain
  3. 3.Multiple Sclerosis and Neuroimmunology UnitDr. Josep Trueta University Hospital, Institut d’Investigació Biomèdica de GironaGironaSpain
  4. 4.Magnetic Resonance Unit, Department of RadiologyVall d’Hebron University HospitalBarcelonaSpain

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