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Neuroinformatics

, Volume 10, Issue 1, pp 81–96 | Cite as

A Library of Cortical Morphology Analysis Tools to Study Development, Aging and Genetics of Cerebral Cortex

  • Peter Kochunov
  • William Rogers
  • Jean-Francois Mangin
  • Jack Lancaster
Original Article

Abstract

Sharing of analysis techniques and tools is among the main driving forces of modern neuroscience. We describe a library of tools developed to quantify global and regional differences in cortical anatomy in high resolution structural MR images. This library is distributed as a plug-in application for popular structural analysis software, BrainVisa (BV). It contains tools to measure global and regional gyrification, gray matter thickness and sulcal and gyral white matter spans. We provide a description of each tool and examples for several case studies to demonstrate their use. These examples show how the BV library was used to study cortical folding process during antenatal development and recapitulation of this process during cerebral aging. Further, the BV library was used to perform translation research in humans and non-human primates on the genetics of cerebral gyrification. This library, including source code and self-contained binaries for popular computer platforms, is available from the NIH-Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC) resource (http://www.nitrc.org/projects/brainvisa_ext).

Keywords

Cortical analysis tools BrainVisa Gray matter thickness Sulcal span Object based morphometry 

Notes

Acknowledgment

This research was supported by the National Institute of Biomedical Imaging and Bioengineering (K01 EB006395) grant to P.K.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Peter Kochunov
    • 1
    • 2
  • William Rogers
    • 1
  • Jean-Francois Mangin
    • 3
  • Jack Lancaster
    • 1
  1. 1.Maryland Psychiatric Research Center, Department of PsychiatryUniversity of Maryland School of MedicineBaltimoreUSA
  2. 2.Southwest Foundation for Biomedical ResearchSan AntonioUSA
  3. 3.NeurospinGif sur YvetteFrance

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