, Volume 8, Issue 1, pp 5–17 | Cite as

The Java Image Science Toolkit (JIST) for Rapid Prototyping and Publishing of Neuroimaging Software

  • Blake C. Lucas
  • John A. Bogovic
  • Aaron Carass
  • Pierre-Louis Bazin
  • Jerry L. Prince
  • Dzung L. Pham
  • Bennett A. LandmanEmail author


Non-invasive neuroimaging techniques enable extraordinarily sensitive and specific in vivo study of the structure, functional response and connectivity of biological mechanisms. With these advanced methods comes a heavy reliance on computer-based processing, analysis and interpretation. While the neuroimaging community has produced many excellent academic and commercial tool packages, new tools are often required to interpret new modalities and paradigms. Developing custom tools and ensuring interoperability with existing tools is a significant hurdle. To address these limitations, we present a new framework for algorithm development that implicitly ensures tool interoperability, generates graphical user interfaces, provides advanced batch processing tools, and, most importantly, requires minimal additional programming or computational overhead. Java-based rapid prototyping with this system is an efficient and practical approach to evaluate new algorithms since the proposed system ensures that rapidly constructed prototypes are actually fully-functional processing modules with support for multiple GUI’s, a broad range of file formats, and distributed computation. Herein, we demonstrate MRI image processing with the proposed system for cortical surface extraction in large cross-sectional cohorts, provide a system for fully automated diffusion tensor image analysis, and illustrate how the system can be used as a simulation framework for the development of a new image analysis method. The system is released as open source under the Lesser GNU Public License (LGPL) through the Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC).


Parallel processing Pipeline Rapid prototyping Image processing MRI 



We greatly appreciate the unwavering support of Matt McAuliffe and Evan McCreedy of the NIH Center for Information Technology and the dedication of our undergraduate interns (Yufeng Guo, Robert Kim, Meenal Patel, Heba Mustufa, Hanlin Wan, and Jie Zhang). This work was supported by NIH/NINDS 5R01NS037747, 1R01NS056307, NIH/NIA N01-AG-4-0012 and NINDS 5R01NS054255.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Blake C. Lucas
    • 1
    • 2
  • John A. Bogovic
    • 1
  • Aaron Carass
    • 1
  • Pierre-Louis Bazin
    • 3
  • Jerry L. Prince
    • 1
    • 3
    • 4
  • Dzung L. Pham
    • 3
  • Bennett A. Landman
    • 4
    • 5
    • 6
    Email author
  1. 1.Department of Electrical and Computer EngineeringJohns Hopkins UniversityBaltimoreUSA
  2. 2.National Institute on AgingNational Institute of HealthBaltimoreUSA
  3. 3.Department of Radiology and Radiological ScienceJohns Hopkins UniversityBaltimoreUSA
  4. 4.Department of Biomedical EngineeringJohns Hopkins UniversityBaltimoreUSA
  5. 5.Department of Electrical EngineeringVanderbilt UniversityNashvilleUSA
  6. 6.Department of Radiology and Radiological SciencesVanderbilt UniversityNashvilleUSA

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