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Blood pressure evaluated by 24 h ambulatory blood pressure monitoring in Ramadan-fasting patients with corticotrope deficiency

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Abstract

Purpose

The risks of Ramadan fasting on blood pressure (BP) in patients with adrenal insufficiency are unknown. This study aimed to evaluate the levels of BP and particularly the risk for hypotension during a fasting day compared with a nonfasting day in patients with corticotrope deficiency.

Methods

A prospective case-crossover study on 28 patients with known and treated corticotrope deficiency who were fasting the month of Ramadan. Clinical (eating and sleeping habits, abnormal symptoms, weight, height, and BP) and paraclinical (creatinine, sodium, and cortisol) data were collected. Patients had a 24 h ambulatory BP monitoring during a Ramadan fasting day then again during a nonfasting day.

Results

The data of 25 patients were analyzed; 20 women, median age: 40 years (IQR, 22.5–45.5), median duration of the disease: 6 years (IQR, 2.5–12). The prevalence of hypotension did not differ between the fasting day and the nonfasting day. Hour by hour BP levels comparison showed that both systolic and diastolic BP were significantly lower at 2.00 p.m. during fasting. BP variability was significantly lower during the fasting period compared with the same period during the nonfasting day.

Conclusions

Fasting was not associated with an increased risk for hypotension in patients with known and treated corticotrope deficiency.

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Acknowledgements

The authors thank Professor Alaya Kacem for language assistance.

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Authors and Affiliations

  1. Department of Endocrinology, University Hospital La Rabta, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia

    Melika Chihaoui, Wafa Grira, Fatma Chaker, Ibtissem Oueslati, Zohra Ben Amor & Meriem Yazidi

  2. Department of Biochemistry, Faculty of Medicine of Tunis, University Hospital La Rabta, University of Tunis El Manar, Tunis, Tunisia

    Moncef Feki

Authors
  1. Melika Chihaoui
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  2. Wafa Grira
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  3. Fatma Chaker
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  4. Ibtissem Oueslati
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  5. Zohra Ben Amor
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  6. Meriem Yazidi
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  7. Moncef Feki
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Corresponding authors

Correspondence to Melika Chihaoui or Moncef Feki.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the University Hospital La Rabta of Tunis and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Chihaoui, M., Grira, W., Chaker, F. et al. Blood pressure evaluated by 24 h ambulatory blood pressure monitoring in Ramadan-fasting patients with corticotrope deficiency. Endocrine 68, 210–214 (2020). https://doi.org/10.1007/s12020-020-02213-8

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  • DOI: https://doi.org/10.1007/s12020-020-02213-8

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