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Dual-release hydrocortisone for treatment of adrenal insufficiency: a systematic review

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Abstract

Dual-release hydrocortisone is a new hydrocortisone formulation developed to improve the pharmacokinetic and the pharmacodynamic profiles and patient compliance. The aim of this review is to summarize the main knowledge on dual-release hydrocortisone, with particular attention to pharmacokinetics, metabolic and health-related quality-of-life aspects, bone health and drug safety.

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This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.

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Correspondence to Aldo Eugenio Calogero.

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Mongioì, L.M., Condorelli, R.A., Barbagallo, F. et al. Dual-release hydrocortisone for treatment of adrenal insufficiency: a systematic review. Endocrine (2020) doi:10.1007/s12020-020-02187-7

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Keywords

  • Adrenal insufficiency
  • Dual-release hydrocortisone
  • Pharmacokinetic
  • Metabolism