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Endocrine

pp 1–10 | Cite as

Relation of adipose tissue insulin resistance to prediabetes

  • Jing Wen
  • Xueli Cai
  • Jie Zhang
  • Jiajia Jiang
  • Wei Li
  • Guangxu Liu
  • Meiping Wang
  • Herbert Y. Gaisano
  • Yuesong PanEmail author
  • Yan HeEmail author
Original Article

Abstract

Purpose

The degree of adipose tissue insulin resistance increases in obesity, prediabetes and type 2 diabetes, but whether it associates with prediabetes is unclear.

Methods

This is a cross-sectional study of 426 participants. The degree of adipose tissue insulin resistance was assessed using the index of adipose tissue insulin resistance (Adipo-IRI), calculated as the product of fasting insulin and free fatty acids. The association of adipose tissue insulin resistance and prediabetes was assessed by multivariate logistic regression. Area under curves (AUCs) of receiver operating characteristic cure analyses were calculated to assess their diagnostic value in distinguishing prediabetes of the following: insulin resistance in the adipose tissue and peripheral tissue, general and abdominal obesity, and elevated triglycerides.

Results

The median age of the participants was 59 years with males accounting for 47.7%. After adjustment for potential confounding factors, Adipo-IRI was associated with prediabetes and its phenotypes in both genders. The diagnostic value of adipose tissue insulin resistance (AUC, male: 0.71 (95% CI, 0.65–0.77) and female: 0.74 (95% CI, 0.68–0.95)) for prediabetes were superior or similar to peripheral tissue insulin resistance, body mass index, waist circumference and triglycerides.

Conclusions

Adipose tissue insulin resistance is associated with prediabetes and should be considered for use in population studies.

Keywords

Adipose tissue insulin resistance Prediabetes Association Diagnostic value Indicator 

Notes

Acknowledgements

All authors appreciate the efforts of all participants who contributed to sample measurements and data collection.

Funding

This study was funded by the National Natural Science Foundation of China (31672375, 81971091), Beijing Municipal Administration of Hospitals (QML20190501), and the Ministry of Science and Technology of the People’s Republic of China (2017YFC1310902, 2018YFC1311700, and 2018YFC1311706).

Author contributions

Each author has been involved in and contributed to this paper. JW and XC carried out the statistical analyses and drafted the paper. They contributed equally to this study and share first authorship. JJ, GL and MW participated in the data analysis. JZ and WL participated in the literature search. XC and YP participated in the data collection, study management and study coordination. HYG and YP contributed to editing the paper to correct English. YH and YP contributed to the study design and review of this paper. All authors read and approved the final paper.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The study protocol was reviewed and approved by the Committee on Human Research of Lishui Central Hospital, and all procedures were performed in accordance with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Informed consent

The study methods and potential risks were fully explained to all participants, and each participant provided a written informed consent prior to enrollment.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2020

Authors and Affiliations

  1. 1.Department of Epidemiology and Biostatistics, School of Public HealthCapital Medical UniversityBeijingChina
  2. 2.Department of NeurologyLishui Municipal Central HospitalLishuiChina
  3. 3.Municipal Key Laboratory of Clinical EpidemiologyBeijingChina
  4. 4.Department of MedicineUniversity of TorontoTorontoCanada
  5. 5.China National Clinical Research Center for Neurological DiseasesBeijingChina
  6. 6.Department of Neurology, Beijing Tiantan HospitalCapital Medical UniversityBeijingChina

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