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Endocrine

pp 1–8 | Cite as

Spectral domain optical coherence tomography based imaging biomarkers for diabetic retinopathy

  • Sandeep SaxenaEmail author
  • Martin Caprnda
  • Surabhi Ruia
  • Senthamizh Prasad
  • Ankita
  • Julia Fedotova
  • Peter KruzliakEmail author
  • Vladimir Krasnik
Original Article

Abstract

To evaluate the role of central subfield thickness (CST), cube average thickness (CAT), and cube volume (CV) as imaging biomarkers for severity of diabetic retinopathy within the ETDRS-based grades of retinopathy using spectral domain optical coherence tomography (SD-OCT). This study aims to evaluate the role of macular CST, CAT, and CV on SD-OCT as imaging biomarkers for severity of DR. One hundred ninety-four consecutive cases of type 2 diabetes mellitus were divided according to ETDRS classification: diabetes mellitus without retinopathy (No DR; n = 65), nonproliferative diabetic retinopathy (NPDR; n = 66), and proliferative diabetic retinopathy (PDR; n = 63). Sixty-three healthy controls were included. CST, CAT, and CV were analyzed using SD-OCT. Data were analyzed statistically. Analysis of variance revealed a significant increase in levels of CST, CAT, CV, and LogMAR visual acuity with the increase in severity of DR. Independent t-test revealed significant difference in CST, CAT, and CV between cases with DME and cases without DME. On multivariate linear regression analysis, increase in CST, CAT, and CV were found to indicate the increase in severity of DR. SD-OCT-based imaging biomarkers CST, CAT, and CV are effective tools for documenting the severity of diabetic retinopathy. These imaging biomarkers serve as significant indicators of severity of disease.

Keywords

Diabetic retinopathy Diabetic macular edema Central subfield thickness Cube average thickness Cube volume Spectral-domain optical coherence tomography 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of OphthalmologyKing George’s Medical UniversityLucknowIndia
  2. 2.1st Department of Internal Medicine, Faculty of MedicineComenius University and University HospitalBratislavaSlovakia
  3. 3.Department of Community MedicineKing George’s Medical UniversityLucknowIndia
  4. 4.Laboratory of Neuroendocrinology, I.P. Pavlov Institute of PhysiologyRussian Academy of Sciences, StPetersburgRussia
  5. 5.Department of Chemistry and Molecular BiologyITMO University, StPetersburgRussia
  6. 6.Department of Internal MedicineBrothers of Mercy HospitalBrnoCzech Republic
  7. 7.2nd Department of Surgery, Faculty of MedicineMasaryk University and St. Anne´s University HospitalBrnoCzech Republic
  8. 8.Department of Ophthalmology, Faculty of MedicineComenius University and University HospitalBratislavaSlovakia

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