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Endocrine

, Volume 66, Issue 3, pp 691–692 | Cite as

Synchronous bilateral pheochromocytomas and bilobar medullary thyroid carcinoma revealed by 18F-FDOPA PET/CT in a MEN-2A asymptomatic patient

  • Marianela Rotania
  • Gérard Chabrier
  • Alessio ImperialeEmail author
Endocrine imaging
  • 26 Downloads

Type-2A multiple endocrine neoplasia (MEN-2A) syndrome is a rare autosomal dominant inheritance disease characterized by the presence of pheochromocytoma (PHEO), medullary thyroid carcinoma (MTC), and parathyroid adenoma or hyperplasia. In patients with MEN-2A, PHEO is frequently asymptomatic and bilateral, and MTC is multifocal, usually representing the first manifestation of the disease.

Herein, we present the scholar clinical case of a 38-years-old woman with MEN-2A syndrome addressed for clinical examination and primary biochemical investigation following the diagnosis of a mutation in codon 634 of gene RET exon 11. Patient showed increased plasma normetanephrine (14.7 nmol/l, normal <10.9), noradrenaline (680 ng/l, normal <400), adrenaline (257 ng/l, normal <90), dopamine (64 ng/l, normal <50), chromogranin-A (114 ug/L, normal <100), and calcitonin values (241 ng/L, normal <10). At clinical examination, small non-toxic goiter (afterwards confirmed by cervical ultrasonography) was...

Notes

Funding

This research received no external funding.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

References

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    D. Taïeb, R.J. Hicks, E. Hindié, B.A. Guillet, A. Avram, P. Ghedini et al. European association of nuclear medicine practice guideline/society of nuclear medicine and molecular imaging procedure standard 2019 for radionuclide imaging of phaeochromocytoma and paraganglioma. Eur. J. Nucl. Med. Mol. Imaging 46, 2112–2137 (2019)CrossRefGoogle Scholar
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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Marianela Rotania
    • 1
    • 2
  • Gérard Chabrier
    • 3
  • Alessio Imperiale
    • 1
    • 4
    • 5
    Email author
  1. 1.Biophysics and Nuclear Medicine, Hautepierre HospitalUniversity Hospitals of StrasbourgStrasbourgFrance
  2. 2.Molecular and Nuclear MedicineInstituto OultonCordobaArgentina
  3. 3.Endocrinology and Internal Medicine Department, Hautepierre HospitalUniversity Hospitals of StrasbourgStrasbourgFrance
  4. 4.Faculty of Medicine, FMTSUniversity of StrasbourgStrasbourgFrance
  5. 5.Molecular Imaging—DRHIM, IPHC, UMR 7178, CNRS/UnistraStrasbourgFrance

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