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Endocrine

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Adrenal insufficiency treated with conventional hydrocortisone leads to elevated levels of Interleukin-6: a pilot study

  • Amir-Hossein RahvarEmail author
  • Martin Riesel
  • Tobias Graf
  • Birgit Harbeck
Research Letter
  • 14 Downloads

Adrenal insufficiency is a rare disease with an estimated prevalence of 100–126 cases per million for primary adrenal insufficiency (PAI) and 450 cases per million for secondary/tertiary adrenal insufficiency (SAI/TAI) [1, 2]. Glucocorticoid replacement therapy (GRT) is the gold standard and only viable treatment for AI [3]. The present guideline on PAI recommends the use of hydrocortisone (HC) or prednisolone for GRT [3]. However, currently used GRT regimens inadequately mimic the physiological rhythm of endogenous cortisol secretion leading to temporary hypercortisolism and hypocortisolism [4]. The consequences of these conditions are not completely understood but may be associated with deleterious effects on body composition [5]. In fact, patients with AI on GRT have an increased cardiovascular and cerebrovascular mortality [6, 7].

Since inflammation is known to have a role in the pathogenesis of cardiovascular diseases, measurement of inflammatory markers has been suggested for...

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of MedicineUniversity Medical Center Hamburg-EppendorfHamburgGermany
  2. 2.University of LuebeckLuebeckGermany
  3. 3.Department of CardiologyUniversity Hospital LuebeckLuebeckGermany
  4. 4.MVZ Amedes Experts, EndocrinologyHamburgGermany

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