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Cellular markers in corticotroph adenomas correlate with hormones–concerns on interpretation

  • Xiaopeng Guo
  • Bing XingEmail author
Letter to the Editor

Dear Editor,

We read with great interest the article written by Lim et al. [1]. (Hormonal aggressiveness according to the expression of cellular markers in corticotroph adenomas; Endocrine, 24 Nov 2018. Since the associations between the expressions of cellular markers of corticotroph adenomas and the hormone levels in patients with Cushing’s Disease (CD) were not clear, the authors investigated the associations between these indices and found that although pituitary tumor-transforming gene 1 (PTTG1) and Ki-67 were highly expressed compared with other markers in tumor tissue, they did not reflect hormone levels. On the contrary, the expressions of cyclin D1, p27, and brahma related-gene 1 (Brg1) had better correlations with hormone levels. This article gives us a fresh view of the predictive function of tumor cellular markers to hormone levels in patients with CD, but some points need to be addressed.

First, the audience of this article,...


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.


  1. 1.
    J. S. Lim, M. K. Lee, E. Choi, N. Hong, I. Jee S, S. H. Kim, E. J. Lee, Hormonal aggressiveness according to the expression of cellular markers in corticotroph adenomas. Endocrine (2018).
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    E. Chatzellis, K.I. Alexandraki, I.I. Androulakis, G. Kaltsas, Aggressive Pituitary Tumors. Neuroendocrinology 101(2), 87–104 (2015). CrossRefPubMedGoogle Scholar
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    O. Ragnarsson, D. S. Olsson, E. Papakokkinou, D. Chantzichristos, P. Dahlqvist, E. Segerstedt, T. Olsson, M. Petersson, K. Berinder, S. Bensing, C. Höybye, B. Edén-Engström, P. Burman, L. Bonelli, C. Follin, D. Petranek, E. M. Erfurth, J. Wahlberg, B. Ekman, A. K. Åkerman, E. Schwarcz, I. L. Bryngelsson, G. Johannsson, Overall and disease-specific mortality in patients with Cushing’s disease: a Swedish nationwide study. J. Clin. Endocrinol. Metab. (2019).

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina
  2. 2.China Pituitary Disease Registry CenterChinese Pituitary Adenoma Cooperative GroupBeijingChina

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