F18-choline/C11-choline PET/CT thyroid incidentalomas
- 9 Downloads
Thyroid incidentaloma is defined as a thyroid lesion incidentally and newly detected by imaging techniques performed for an unrelated purpose and especially for a non-thyroid disease. Aim of this review is to evaluate the prevalence and clinical significance of focal incidental radiolabelled choline uptake in the thyroid gland (CTI) revealed by PET or PET/CT.
A comprehensive computer literature search of the PubMed/MEDLINE, Scopus, and Embase databases was conducted to find relevant published articles about the prevalence and clinical significance of CTIs detected by PET or PET/CT in patients studied for other oncologic purposes.
Fifteen articles (14 case reports, one retrospective study on a larger population sample) were included in the systematic review. Considering the case reports, 7/14 CTIs were benign and 7/14 malignant. In the retrospective study on a larger population sample, 14/15 CTIs which underwent further investigations were benign.
Despite very rare but probably underestimated, CTIs frequently signal in the presence of unexpected lesions in the thyroid that differ from the indicated reason for which the patient was initially scanned, and the risk of malignancy is not negligible.
KeywordsThyroid Incidental Thyroid incidentaloma Choline PET/CT Positron emission tomography
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
This article does not contain any studies with human participants performed by any of the authors.
- 3.M. Picchio, C. Messa, C. Landoni, L. Gianolli, S. Sironi, M. Brioschi, M. Matarrese, D.V. Matei, F. De Cobelli, A. Del Maschio, F. Rocco, P. Rigatti, F. Fazio, Value of [11C]choline-positron emission tomography for re-staging prostate cancer: a comparison with [18F]fluorodeoxyglucose-positron emission tomography. J. Urol. 169, 1337–1340 (2003)CrossRefGoogle Scholar
- 4.T.R. DeGrado, R.E. Reiman, D.T. Price, S. Wang, R.E. Coleman, Pharmacokinetics and radiation dosimetry of 18F-fluorocholine. J. Nucl. Med. 43, 92–96 (2002)Google Scholar
- 12.G. Paone, G. Treglia, M. Bongiovanni, T. Ruberto, L. Ceriani, L. Giovanella, Incidental detection of Hürthle cell adenoma by 18F-choline PET/CT scan in a patient with prostate cancer. Rev. Esp. Med. Nucl. Imagen Mol. 32, 340–341 (2013)Google Scholar
- 13.R. Ciappuccini, C. Jeanne, S. Bardet. Incidental focal thyroid uptake on 18F-Choline PET-CT: need to rule out thyroid cancer. Endocrine.(2018). https://doi.org/10.1007/s12020-018-1705-2.
- 19.A. Haroon, L. Zanoni, M. Celli, R. Zakavi, M. Beheshti, W. Langsteger, S. Fanti, M. Emberton, J. Bomanji, Multicenter study evaluating extraprostatic uptake of 11C-choline, 18F-methylcholine, and 18F-ethylcholine in male patients: physiological distribution, statistical differences, imaging pearls, and normal variants. Nucl. Med. Commun. 36, 1065–1075 (2015)CrossRefGoogle Scholar
- 21.O. Schillaci, F. Calabria, M. Tavolozza, C. Cicciò, M. Carlani, C.R. Caracciolo, R. Danieli, A. Orlacchio, G. Simonetti, 18F-choline PET/CT physiological distribution and pitfalls in image interpretation: experience in 80 patients with prostate cancer. Nucl. Med. Commun. 31, 39–45 (2010)CrossRefGoogle Scholar
- 23.R. Ruiz-Esponda, V.J. Lowe, D.S. Dean. Clinical significance of incidental thyroid uptake on 11Ccholine PET/CT. Endo. Rev. 35 SUPPL (2014).Google Scholar
- 24.A.M. García Vicente, A. Núñez García, A.M. Soriano Castrejón, G.A. Jiménez Londoño, J.M. Cordero García, A. Palomar Muñoz, Pitfalls with 18F-choline PET/CT in patients with prostate cancer. Rev. Esp. Med. Nucl. Imagen Mol. 32, 37–39 (2013)Google Scholar
- 28.F. Bertagna, G. Treglia, A. Piccardo, E. Giovannini, G. Bosio, G. Biasiotto, K. Bahij el, R. Maroldi, R. Giubbini, F18-FDG-PET/CT thyroid incidentalomas: a wide retrospective analysis in three Italian centres on the significance of focal uptake and SUV value. Endocrine 43, 678–685 (2013)CrossRefGoogle Scholar
- 31.S. Grimaldi, J. Young, P. Kamenicky, D. Hartl, M. Terroir, S. Leboulleux, A. Berdelou, J. Hadoux, S. Hescot, H. Remy, E. Baudin, M. Schlumberger, D. Deandreis, Challenging pre-surgical localization of hyperfunctioning parathyroid glands in primary hyperparathyroidism: the added value of 18F-Fluorocholine PET/CT. Eur. J. Nucl. Med. Mol. Imaging 45, 1772–1780 (2018)CrossRefGoogle Scholar