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Skeletal fragility: an emerging complication of Ehlers–Danlos syndrome

  • Anna Maria Formenti
  • Mauro Doga
  • Stefano Frara
  • Marco Ritelli
  • Marina Colombi
  • Giuseppe Banfi
  • Andrea GiustinaEmail author
Clinical Management of Endocrine Diseases


Ehlers–Danlos syndrome (EDS) is an emerging cause of skeletal fragility. Mechanism of bone damage are probably multifactorial in line with the different skeletal phenotypes that can be found in clinical practice. A structured approach to clinical management of bone metabolic complication in EDS is proposed.


Osteoporosis Vertebral fractures Ehlers–Danlos syndrome Bone mineral density Bone structure 


Compliance with ethical standards

Conflict of interest

A.G. is consultant for Abiogen. The remaining authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any experimental studies with human participants performed by any of the authors. Data collected from routine evaluation of two patients are reported.

Informed consent

Informed consent was obtained from the two patients whose routine data were reported in the manuscript.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Anna Maria Formenti
    • 1
  • Mauro Doga
    • 2
  • Stefano Frara
    • 2
  • Marco Ritelli
    • 3
  • Marina Colombi
    • 3
  • Giuseppe Banfi
    • 1
    • 2
  • Andrea Giustina
    • 2
    Email author
  1. 1.IRCCSIstituto Ortopedico GaleazziMilanoItaly
  2. 2.Vita-Salute San Raffaele UniversityMilanoItaly
  3. 3.Department of Molecular and Translational MedicineUniversity of BresciaBresciaItaly

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