Increased waist-to-hip ratio is associated with decreased urine glucose excretion in adults with no history of diabetes
- 78 Downloads
Promoting urine glucose excretion (UGE) is an attractive approach for the treatment of diabetes. Obesity is associated with increased risk for type 2 diabetes. This study was aimed to investigate the association of waist-to-hip ratio (WHR), a simple measure of abdominal obesity, with UGE determined in subjects without previous history of diabetes.
We studied the correlation of WHR with UGE in 7485 participants without previous history of diabetes. All participants were given a standard 75 g glucose solution. Clinical parameters and demographic characteristics were assessed. Multiple linear regression analysis and multivariate logistic regression analysis were performed to determine the association of WHR with UGE.
Individuals with high WHR (H-WHR) exhibited significantly lower UGE compared to those with low WHR (L-WHR), in either normal glucose tolerance group or pre-diabetes group. In newly diagnosed diabetes group, individuals with H-WHR also showed lower UGE than those with L-WHR; however, no statistical significance was observed. After adjustment for potential confounding factors, including age, genders, and blood glucose level, WHR was negatively associated with UGE (β = −250.901, 95% CI: −471.891 to −29.911, p = 0.026). However, no significant association was observed between BMI and UGE. Furthermore, multivariable logistic regression model showed that individuals with H-WHR were more likely to have low UGE (OR = 0.83, 95% CI: 0.71–0.97, p = 0.018).
Individuals with H-WHR were at risk for decreased UGE. This study suggests that WHR, but not BMI, might be an important determinant of UGE.
KeywordsUrine glucose excretion Obesity Waist-to-hip ratio Renal glucose reabsorption
We owe our sincere thanks to the local research teams and colleagues for assistance in participant recruitment. We are grateful to many residents of Jiangsu Province who participated in this study. We thank all the staff who were involved in this study for their important contributions.
This study was supported by grants from the Excellence Project of Southeast University, the National Key R&D Program of China (2016YFC1305700) and the National Key Scientific Instrument and Equipment Development Project of China (No. 51627808). The funders had no roles in study design, data collection, data analysis, interpretation or writing the manuscript.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This study was approved by the ethical review committee of Jiangsu Provincial Center for Disease Control and Prevention (JSJK2016-B003-03).
Informed consent was obtained from all participants included in the study.
- 3.R.A. DeFronzo, M. Hompesch, S. Kasichayanula, X. Liu, Y. Hong, M. Pfister, L.A. Morrow, B.R. Leslie, D.W. Boulton, A. Ching, F.P. LaCreta, S.C. Griffen, Characterization of renal glucose reabsorption in response to dapagliflozin in healthy subjects and subjects with type 2 diabetes. Diabetes Care 36, 3169–3176 (2013)CrossRefGoogle Scholar
- 7.J. Chen, H. Guo, S. Yuan, C. Qu, T. Mao, S. Qiu, W. Li, X. Wang, M. Cai, H. Sun, B. Wang, X. Li, Z. Sun, Efficacy of urinary glucose for diabetes screening: a reconsideration. Acta Diabetol. (2018). https://doi.org/10.1007/s00592-018-1212-1
- 8.J. Lu, R.F. Bu, Z.L. Sun, Q.S. Lu, H. Jin, Y. Wang, S.H. Wang, L. Li, Z.L. Xie, B.Q. Yang, Comparable efficacy of self-monitoring of quantitative urine glucose with self-monitoring of blood glucose on glycaemic control in non-insulin-treated type 2 diabetes. Diabetes Res. Clin. Pract. 93, 179–186 (2011)CrossRefGoogle Scholar
- 14.X.D. Yue, J.Y. Wang, X.R. Zhang, J.H. Yang, C.Y. Shan, M.Y. Zheng, H.Z. Ren, Y. Zhang, S.H. Yang, Z.H. Guo, B. Chang, B.C. Chang, Characteristics and impact factors of renal threshold for glucose excretion in patients with type 2 diabetes mellitus. J. Korean Med. Sci. 32, 621–627 (2017)CrossRefGoogle Scholar
- 15.S. Yusuf, S. Hawken, S. Ounpuu, L. Bautista, M.G. Franzosi, P. Commerford, C.C. Lang, Z. Rumboldt, C.L. Onen, L. Lisheng, S. Tanomsup, P. Wangai, F. Razak, A.M. Sharma, S.S. Anand, Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study. Lancet 366, 1640–1649 (2005)CrossRefGoogle Scholar
- 16.J.P. Reis, C.A. Macera, M.R. Araneta, S.P. Lindsay, S.J. Marshall, D.L. Wingard, Comparison of overall obesity and body fat distribution in predicting risk of mortality. Obesity (Silver Spring) 17, 1232–1239 (2009)Google Scholar
- 17.J. Chen, H.J. Guo, S.H. Qiu, W. Li, X.H. Wang, M. Cai, B. Wang, X.N. Li, Z.L. Sun, Identification of newly diagnosed diabetes and prediabetes using fasting plasma glucose and urinary glucose in a Chinese population: a multicenter cross-sectional study. Chin. Med. J. 131, 1652–1657 (2018)CrossRefGoogle Scholar
- 22.S.B. Solerte, M. Fioravanti, S. Severgnini, M. Rondanelli, S. Precerutti, G. Vignati, E. Ferrari, Hyperinsulinemia and glucagon serum concentrations influence renal hemodynamics and urinary protein loss in normotensive patients with central obesity. Int. J. Obes. Relat. Metab. Disord. 24(Suppl 2), S122–S123 (2000)CrossRefGoogle Scholar