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Endocrine

, Volume 62, Issue 3, pp 528–534 | Cite as

The effects of metformin on simple obesity: a meta-analysis

  • Hong-Hong Ning
  • Jiong Le
  • Qian Wang
  • Charlotte Aimee Young
  • Bo Deng
  • Peng-Xiang Gao
  • Hai-Qiao Zhang
  • Shu-Lan Qin
Meta-Analysis
  • 266 Downloads

Abstract

Objective

To evaluate the efficacy of metformin versus a placebo in the treatment of patients with simple obesity without obesity related diseases.

Methods

A search was done on Pub-Med, EMBASE, Cochrane, and Science Citation Index Expanded databases. The main inclusion criteria included the following:(1) randomized controlled trials. (2) patients diagnosed as being overweight or obese. (3) patients were randomly assigned to receive metformin or control. Exclusion criteria included the following: patients diagnosed with an obesity related disease, such as diabetes mellitus (DM) or polycystic ovary syndrome (PCOS).

Results

Compared with the placebo, weighted mean difference (WMD) was 2.33 (95% CI 0.31, 4.35) kg higher with metformin (p = 0.02). Compared with the placebo, WMD was 0.57 (95% CI 0.35, 0.79) kg/m² higher with metformin(p < 0.00001). There was no significant difference in the reduction of waist circumference between the metformin group and the control group (p = 0.05). The fasting blood glucose levels were significantly lower in the metformin group than in the control group (p < 0.00001). However, no hypoglycemia was noted in the metformin group or the control group.

Conclusion

Metformin is effective in reducing body weight of simple obesity patients, and metformin does not induce hypoglycemia as a side effect.

Keywords

Metformin Obesity Overweight Weight loss Meta-analysis 

Notes

Funding

This study was funded by the health and family planning commission of jiang-xi provincial for the research of science and technology (20171964).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Hong-Hong Ning
    • 1
  • Jiong Le
    • 2
  • Qian Wang
    • 1
  • Charlotte Aimee Young
    • 3
  • Bo Deng
    • 1
  • Peng-Xiang Gao
    • 1
  • Hai-Qiao Zhang
    • 1
  • Shu-Lan Qin
    • 1
  1. 1.Department of Endocrinology, Third Affiliated HospitalNanchang UniversityNanchangChina
  2. 2.Jiangxi Aerospace Icloud Science and Technology Co., Ltd.NanchangChina
  3. 3.Department of OphthalmologyUniversity of CaliforniaSan FranciscoUSA

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