Association of type 2 diabetes susceptible genes GCKR, SLC30A8, and FTO polymorphisms with gestational diabetes mellitus risk: a meta-analysis
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Current studies have detected the correlation of polymorphisms in type 2 diabetes susceptible genes GCKR, SLC30A8 and FTO with gestational diabetes mellitus (GDM) risk. However, findings of these studies were incongruous. Hence, we performed an integrated review and meta-analysis for the researches regarding the association of single nucleotide polymorphisms (SNPs) in GCKR, SLC30A8 and FTO genes and GDM risk.
Eligible publications were selected on the basis of several inclusion and exclusion criteria. Correlation between each SNP and GDM risk was estimated by computing odds ratios (ORs) with 95% confidence intervals (95%CIs).
Consequently, 19 case-control studies (from 16 citations) including 3636 GDM cases and 7229 GDM-free controls were participated in a meta-analysis of seven prevalent SNPs (GCKR rs1260326 and rs780094; SLC30A8 rs13266634 and rs11558471; FTO rs8050136, rs1421085 and rs9939609). Our results demonstrated that the rs780094, rs13266634 and rs9939609 SNPs were significantly associated with GDM risk. In stratified analysis, correlations of rs780094 and rs13266634 SNPs could be observed in Asian and Caucasian subgroups. Moreover, association between rs9939609 SNP and GDM risk was detected in Caucasian subgroup.
The GCKR rs780094, SLC30A8 rs13266634 and FTO rs9939609 SNPs were demonstrated to be the potential biomarkers for GDM risk prediction.
KeywordsGCKR SLC30A8 FTO Single nucleotide polymorphism Gestational diabetes mellitus Risk
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Conflict of interest
The authors declare that they have no conflict of interest.
- 4.Diagnostic criteria and classification of hyperglycaemia first detected in pregnancy: a World Health Organization Guideline. Diabetes Res. Clin. Pract. 103(3), 341–363 (2014)Google Scholar
- 31.A.M. Stuebe et al. Maternal genotype and gestational diabetes. Am. J. Perinatol. 31(1), 68–76 (2014)Google Scholar
- 37.I. Kim et al. A low-risk ZnT-8 allele (W325) for post-transplantation diabetes mellitus is protective against cyclosporin A-induced impairment of insulin secretion. Pharm. J. 11(3), 191–198 (2011)Google Scholar
- 40.A. Teleginski et al. Leptin (rs7799039) and solute carrier family 30 zinc transporter (rs13266634) polymorphisms in Euro-Brazilian pregnant women with gestational diabetes. Genet. Mol. Res. 16(1) (2017)Google Scholar
- 47.S. Jamalpour et al. A case-control study and meta-analysis confirm glucokinase regulatory gene rs780094 is a risk factor for gestational diabetes mellitus. Gene 125(7):784-793 (2018)Google Scholar
- 52.A. Pagan et al. A gene variant in the transcription factor 7-like 2 (TCF7L2) is associated with an increased risk of gestational diabetes mellitus. Int. J. Endocrinol. 180, 77–82 (2014)Google Scholar
- 53.M. He et al. Association of rs13266634 polymorphism in zinc transporter solute carrier family 30-member 8 gene with gestational diabetes mellitus. Chin. J. Diabetes Mellit. 5(1), 38–43 (2013)Google Scholar