, Volume 57, Issue 3, pp 464–473 | Cite as

Liraglutide improves cardiac function in patients with type 2 diabetes and chronic heart failure

  • F. Arturi
  • E. Succurro
  • S. Miceli
  • C. Cloro
  • M. Ruffo
  • R. Maio
  • M. Perticone
  • G. Sesti
  • F. PerticoneEmail author
Original Article



To compare the effect of liraglutide, sitagliptin and insulin glargine added to standard therapy on left ventricular function in post-ischemic type-2 diabetes mellitus patients.


We evaluated 32 type-2 diabetes mellitus Caucasians with history of post-ischemic chronic heart failure NYHA class II/III and/or left ventricular ejection fraction ≤45 %. Participants underwent laboratory determinations, electrocardiogram, echocardiogram, Minnesota Living with Heart Failure questionnaire and 6 min walking test at baseline and following 52 weeks treatment. Patients were treated with standard therapy for chronic heart failure and were randomized to receive liraglutide, sitagliptin and glargine in addition to metformin and/or sulfonylurea.


Liraglutide treatment induced an improvement in left ventricular ejection fraction from 41.5 ± 2.2 to 46.3 ± 3 %; P = 0.001). On the contrary, treatment with sitagliptin and glargine induced no changes in left ventricular ejection fraction (41.8 ± 2.6 vs. 42.5 ± 2.5 % and 42 ± 1.5 vs. 42 ± 1.6 %, respectively; P = NS). Indexed end-systolic LV volume was reduced only in liraglutide-treated patients (51 ± 9 vs. 43 ± 8 ml/m2; P < 0.05). Liraglutide treatment induced also a significant increase in the anterograde stroke volume (39 ± 9 vs. 49 ± 11 ml; P < 0.05), whereas no differences were observed in the other two groups. Cardiac output and cardiac index showed a significant increase only in liraglutide-treated patients (4.4 ± 0.5 vs. 5.0 ± 0.6 L/min; P < 0.05 and 1.23 ± 0.26 vs. 1.62 ± 0.29 L/m2; P = 0.005, respectively).

Liraglutide treatment was also associated with an improvement of functional capacity and an improvement of quality of life.


These data provide evidence that treatment with liraglutide is associated with improvement of cardiac function and functional capacity in failing post-ischemic type-2 diabetes mellitus patients.


Chronic heart failure Type 2 diabetes Liraglutide Glucagon-like peptide-1 Left ventricular ejection fraction Cardiac function 



The authors declare that they have no acknowledgments.


The authors declare that this research did not receive any specific grant from any funding agency in the public, commercial or not-for profit sector

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • F. Arturi
    • 1
  • E. Succurro
    • 1
  • S. Miceli
    • 1
  • C. Cloro
    • 2
  • M. Ruffo
    • 1
  • R. Maio
    • 3
  • M. Perticone
    • 4
  • G. Sesti
    • 1
  • F. Perticone
    • 1
    Email author
  1. 1.Department of Medical and Surgical SciencesUniversity “Magna Graecia” of Catanzaro, Policlinico “Mater Domini”, Campus UniversitarioCatanzaroItaly
  2. 2.Unit of Cardiology “S.S. Annunziata” Hospital of CosenzaCosenzaItaly
  3. 3.Azienda Ospedaliera Mater DominiCatanzaroItaly
  4. 4.Department of Clinical and Experimental MedicineUniversity “Magna Graecia” of CatanzaroCatanzaroItaly

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