, Volume 54, Issue 3, pp 578–587 | Cite as

Pulmonary hypertension in thyroid diseases

  • Pietro Scicchitano
  • Ilaria Dentamaro
  • Francesco Tunzi
  • Gabriella Ricci
  • Santa Carbonara
  • Fiorella Devito
  • Annapaola Zito
  • Anna Ciampolillo
  • Marco Matteo Ciccone


The influence of thyroid hormones on cardiovascular system is well established. Thyroid diseases can effectively enhance the alteration on cardiovascular system by influencing chronotropic and inotropic actions of the heart; altering the strength and the speed of contraction, the speed of relaxation, the duration of the potential of action, and the duration of the refractory period and atrio-ventricular conduction time; modulating circulation and peripheral vascular beds. One of the more intriguing insights in the connection between thyroid diseases and cardiovascular alterations is related to the evaluation of the influence of thyroid hormones on pulmonary vascular beds. Literature reported several studies regarding the association between both hypothyroidism and hyperthyroidism and the occurrence of increased vascular pulmonary arterial pressure. Nevertheless, the pathogenetic mechanisms able to explain such relationship are not fully understood. Many doubts still persist in the comprehension of the mechanisms of pulmonary hypertension in thyroid diseases. The aim of this review was to provide possible explanation about the possible interaction between pulmonary vascular beds and thyroid function in order to evaluate the possibility of novel perspectives in the general management of patients suffering from thyroid and cardiovascular diseases.


Pulmonary hypertension Hyperthyroidism Hypothyroidism Endothelial function Thyroid hormones 


Compliance with ethical standards

Conflict of interest

None declared


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Pietro Scicchitano
    • 1
  • Ilaria Dentamaro
    • 2
  • Francesco Tunzi
    • 3
  • Gabriella Ricci
    • 2
  • Santa Carbonara
    • 2
  • Fiorella Devito
    • 2
  • Annapaola Zito
    • 2
  • Anna Ciampolillo
    • 4
  • Marco Matteo Ciccone
    • 2
  1. 1.Cardiology SectionHospital of Ostuni, ASL BROstuniItaly
  2. 2.Section of Cardiovascular Diseases, Department of Emergency and Organ TransplantationUniversity of BariBariItaly
  3. 3.Cardiology SectionHospital of Gallipoli, ASL LELecceItaly
  4. 4.Section of Endocrinology, Department of Emergency and Organ TransplantationUniversity of BariBariItaly

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