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Endocrine

, Volume 53, Issue 1, pp 327–330 | Cite as

MRI T2 characteristics in somatotroph adenomas following somatostatin analog treatment in acromegaly

  • Ansgar Heck
  • Kyrre E. Emblem
  • Olivera Casar-Borota
  • Geir Ringstad
  • Jens Bollerslev
Research Letter

Introduction

Magnetic resonance imaging (MRI) is the modality of choice to visualize pituitary adenomas in acromegaly. The signal intensity of T2 weighted MRI in somatotroph adenomas correlates with the histological subtypes, baseline characteristics and response to treatment with somatostatin analogs (SSA) [1, 2, 3, 4, 5]. SSA have antisecretory and antiproliferative effects on growth hormone (GH) producing adenomas, but resistance occurs in about a third of the patients treated with first generation SSA [6]. Therefore, T2 intensity may be used as a prognostic marker for response to pre- and postoperative SSA treatment and help guide treatment options in acromegaly [2, 3].

It is not known how SSA treatment affects T2 intensity in somatotroph adenomas. Furthermore, data on SSA treatment and its effect on granulation patterns are lacking. Recently, we have described a method for standardized, quantitative characterization of T2 intensity in GH producing adenomas [5]. In the present...

Keywords

Adenoma Growth Hormone Acromegaly Pituitary Apoplexy Tumour Volume Reduction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Compliance with ethical standards

Disclosure

AH has received speaker fees from Novartis, Ipsen, NovoNordisk, Pfizer and participated in Novartis’ nordic advisory board. KEE has intellectual property rights at NordicNeuroLab AS. JB has received an unrestricted research Grant from Novartis, Pfizer and Merck Norway AS. The other authors have nothing to disclose.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Ansgar Heck
    • 1
    • 2
  • Kyrre E. Emblem
    • 3
  • Olivera Casar-Borota
    • 4
    • 5
  • Geir Ringstad
    • 6
  • Jens Bollerslev
    • 1
    • 2
  1. 1.Section of Specialized Endocrinology, Department of EndocrinologyOslo University Hospital, RikshospitaletOsloNorway
  2. 2.Faculty of MedicineUniversity of OsloOsloNorway
  3. 3.The Intervention CentreOslo University Hospital, RikshospitaletOsloNorway
  4. 4.Department of Immunology, Genetics and PathologyUppsala UniversityUppsalaSweden
  5. 5.Department of PathologyOslo University HospitalOsloNorway
  6. 6.Department of Radiology and Nuclear MedicineOslo University Hospital, RikshospitaletOsloNorway

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