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Endocrine

, Volume 52, Issue 3, pp 541–549 | Cite as

Elevated plasma tumor necrosis factor-α receptor 2 and resistin are associated with increased incidence of kidney function decline in Chinese adults

  • Gang Liu
  • Yueyi Deng
  • Liang Sun
  • Xingwang Ye
  • Pang Yao
  • Yao Hu
  • Feijie Wang
  • Yiwei Ma
  • Huaixing Li
  • Yong Liu
  • Qi SunEmail author
  • Xu LinEmail author
Original Article

Abstract

Adipokines and inflammatory markers have been linked to kidney disease in animal models; however, evidence from prospective human studies is sparse. Recruited from Beijing and Shanghai in 2005, a total number of 2220 non-institutionalized Chinese individuals aged 50–70 years with baseline estimated glomerular filtration rate (eGFR) >60 mL/min/1.73 m2 were prospectively followed for 6 years. Plasma levels of resistin, retinol-binding protein 4 (RBP4), interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-α receptor 2 (TNF-R2) were determined at baseline. Kidney function decrease was assessed by measurements of eGFR over 6 years. Incident-reduced eGFR was defined as the onset of eGFR <60 mL/min/1.73 m2, according to the Modification of Diet in Renal Disease Study Equation for Chinese. During the 6 years of follow-up, 333 (15.0 %) participants had incident-reduced eGFR. Each 1 standard deviation elevated concentration of resistin [relative risk (RR) 1.10; 95 % CI 1.00–1.24] and TNFR-2 (RR 1.30; 95 % CI 1.13–1.49) at baseline were significantly associated with a higher risk of incident-reduced eGFR. Comparing the highest with the lowest quartiles, the RR of incident-reduced eGFR was 1.43 (95 % CI 1.01–2.03) for resistin and 2.03 (95 % CI 1.41–2.93) for TNF-R2 (both P trend < 0.05) after adjustment for baseline demographic characteristics, lifestyle behaviors, BMI, plasma lipid profile, hypertension, and diabetes. These associations remained significant when further controlling for levels of RBP4, IL-6, and CRP, none of which was significantly associated with the risk of incident-reduced eGFR. In this prospective cohort study, elevated levels of resistin and TNF-R2, but not other adipokines and inflammatory markers, were independently associated with a greater risk of kidney function decline in middle-aged and elderly Chinese.

Keywords

Adipokines Inflammatory markers Prospective study Kidney function decline 

Notes

Acknowledgments

This study was supported by the Ministry of Science and Technology of China (2012CB524900 and 2013BAI04B03); the National Natural Science Foundation of China (81202272, 81321062, 30930081, and 81021002); ZY3-CCCX-3-2001, ZYSNXD-CC-HPGC-JD-003; the International Postdoctoral Exchange Fellowship Program 2015; the Knowledge Innovation Program of Shanghai Institutes for Biological Sciences; Chinese Academy of Sciences [2013KIP107]; and the SA-SIBS Scholarship Program.

Compliance with ethical standards

Conflict of interest

The manuscript has neither been published previously, nor under consideration for publication elsewhere. There is no conflict of interest in this study.

Supplementary material

12020_2015_807_MOESM1_ESM.docx (33 kb)
Supplementary material 1 (DOCX 32 kb)

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Gang Liu
    • 1
  • Yueyi Deng
    • 2
  • Liang Sun
    • 1
  • Xingwang Ye
    • 1
  • Pang Yao
    • 1
  • Yao Hu
    • 1
  • Feijie Wang
    • 1
  • Yiwei Ma
    • 1
  • Huaixing Li
    • 1
  • Yong Liu
    • 1
  • Qi Sun
    • 3
    • 4
    Email author
  • Xu Lin
    • 1
    Email author
  1. 1.From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological SciencesChinese Academy of Sciences, and University of Chinese Academy of SciencesShanghaiChina
  2. 2.Department of NephrologyLonghua Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina
  3. 3.Department of NutritionHarvard School of Public HealthBostonUSA
  4. 4.Channing Division of Network Medicine, Department of MedicineBrigham and Women’s Hospital and Harvard Medical SchoolBostonUSA

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