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Endocrine

, Volume 51, Issue 2, pp 205–210 | Cite as

Treating prolactinomas with dopamine agonists: always worth the gamble?

  • Sean Noronha
  • Victoria StokesEmail author
  • Niki Karavitaki
  • Ashley Grossman
Review

Abstract

Dopamine agonists are the treatment of choice for all patients with prolactinomas. They are generally safe, effective, and well-tolerated. However, a link between their use and the development of impulse control disorders has been well recognized in the field of neurology for some time, and evidence for a similar effect in endocrine patients is emerging. This has mainly been revealed through clinical case reports, plus a small number of comparative studies of varying robustness. We review the current available literature and discuss the implications for clinical practice, in particular emphasizing the need for clinicians to be alert to these uncommon but serious adverse effects.

Keywords

Bromocriptine Cabergoline Impulse control Gambling Hypersexuality 

Notes

Acknowledgments

The authors are indebted to Elinor Harriss for her assistance with the literature search.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

References

  1. 1.
    D. Maiter, V. Primeau, 2012 update in the treatment of prolactinomas. Ann. Endocrinol. 73, 90–98 (2012)CrossRefGoogle Scholar
  2. 2.
    F.F. Casanueva, M.E. Molitch, J.A. Schlechte, R. Abs, V. Bonert, M.D. Bronstein, T. Brue, P. Cappabianca, A. Colao, R. Fahlbusch, H. Fideleff, M. Hadani, P. Kelly, D. Kleinberg, E. Laws, J. Marek, M. Scanlon, L.G. Sobrinho, J.A. Wass, A. Giustina, Guidelines of the Pituitary Society for the diagnosis and management of prolactinomas. Clin. Endocrinol. 65, 265–273 (2006)CrossRefGoogle Scholar
  3. 3.
    M.P. Gillam, M.E. Molitch, G. Lombardi, A. Colao, Advances in the treatment of prolactinomas. Endocr. Rev. 27, 485–534 (2006)CrossRefPubMedGoogle Scholar
  4. 4.
    S. Melmed, F.F. Casanueva, A.R. Hoffman, D.L. Kleinberg, V.M. Montori, J.A. Schlechte, J.A. Wass, Endocrine Society, Diagnosis and treatment of hyperprolactinaemia: an Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 96, 273–288 (2011)CrossRefPubMedGoogle Scholar
  5. 5.
    A.B. Moraes, C.M. Silva, L. Vieira Neto, M.R. Gadelha, Giant prolactinomas: the therapeutic approach. Clin. Endocrinol. 79, 447–456 (2013)CrossRefGoogle Scholar
  6. 6.
    B.M. Biller, M.E. Molitch, M.L. Vance, K.B. Cannistraro, K.R. Davis, J.A. Simons, J.R. Schoenfelder, A. Klibanski, Treatment of prolactin-secreting macroadenomas with the once-weekly dopamine agonist cabergoline. J. Clin. Endocrinol. Metab. 81, 2338–2343 (1996)PubMedGoogle Scholar
  7. 7.
    J. Verhelst, R. Abs, D. Maiter, A. van den Bruel, M. Vandeweghe, B. Velkeniers, J. Mockel, G. Lamberigts, P. Petrossians, P. Coremans, C. Mahler, A. Stevenaert, J. Verlooy, C. Raftopoulos, A. Beckers, Cabergoline in the treatment of hyperprolactinaemia: a study in 455 patients. J. Clin. Endocrinol. Metab. 84, 2518–2522 (1999)CrossRefPubMedGoogle Scholar
  8. 8.
    R. Salvatori, Surgical treatment of microprolactinomas: pros. Endocrine 47, 725–729 (2014)CrossRefPubMedGoogle Scholar
  9. 9.
    Position statement on the use of dopamine agonists in endocrine disorders; Society for Endocrinology, Feb 2009 reviewed Nov 2011Google Scholar
  10. 10.
    N. Herring, C. Szmigielski, H. Becher, N. Karavitaki, J.A. Wass, Valvular heart disease and the use of cabergoline for the treatment of prolactinoma. Clin. Endocrinol. 70, 104–108 (2009)CrossRefGoogle Scholar
  11. 11.
    A. Elenkova, R. Shabani, K. Kalinov, S. Zacharieva, Increased prevalence of subclinical cardiac valve fibrosis in patients with prolactinomas on long-term bromocriptine and cabergoline treatment. Eur. J. Endocrinol. 167, 17–25 (2012)CrossRefPubMedGoogle Scholar
  12. 12.
    V. Delgado, N.R. Biermasz, S.W. van Thiel, S.H. Ewe, N.A. Marsan, E.R. Holman, R.A. Feelders, J.W. Smit, J.J. Bax, A.M. Pereira, Changes in heart valve structure and function in patients treated with dopamine agonists for prolactinomas, a 2 year follow-up study. Eur. J. Endocrinol. 77, 99–105 (2012)Google Scholar
  13. 13.
    R.S. Auriemma, R. Pivonello, Y. Perone, L.F. Grasso, L. Ferreri, C. Simeoli, D. Iacuaniello, M. Gasperi, A. Colao, Safety of long-term treatment with cabergoline on cardiac valve disease in patients with prolactinomas. Eur. J. Endocrinol. 169, 359–366 (2013)CrossRefPubMedGoogle Scholar
  14. 14.
    R.S. Auriemma, R. Pivonello, L. Ferreri, P. Priscitelli, A. Colao, Cabergoline use for pituitary tumors and valvular disorders. Endocrinol. Metab. Clin. North Am. 44, 89–97 (2015)CrossRefPubMedGoogle Scholar
  15. 15.
    H. Gu, S. Luck, P.V. Carroll, J. Powrie, J. Chambers, Cardiac valve disease and low-dose dopamine agonist therapy: an artefact of reporting bias? Clin. Endocrinol. 74, 608–610 (2011)CrossRefGoogle Scholar
  16. 16.
    American Psychiatric Association (APA), Diagnostic and Statistical Manual of Mental Disorders—Text Revision (DSM-IV-TR) (APA, Washington, DC, 2000)CrossRefGoogle Scholar
  17. 17.
    J. Ahlskog, Pathological behaviours provoked dopamine agonist therapy of Parkinson’s disease. Physiol. Behav. 104, 168–172 (2011)CrossRefPubMedGoogle Scholar
  18. 18.
    P. Seeman, Parkinson’s disease treatment may cause impulse-control disorder via dopamine D3 receptors. Synapse 69, 183–189 (2015)CrossRefPubMedGoogle Scholar
  19. 19.
    V.S. Premaratne, I. Saeger, B.K. Macdonald, Lesson of the month (1): cabergoline - ‘I eat funny on that’. Clin. Med. 14, 205–507 (2014)CrossRefGoogle Scholar
  20. 20.
    J.R. Cornelius, M. Tippmann-Peikert, N.L. Slocumb, C.F. Frerichs, M.H. Silber, Impulse control disorders with the use of dopaminergic agents in restless legs syndrome: a case-control study. Sleep 33, 81–87 (2010)PubMedPubMedCentralGoogle Scholar
  21. 21.
    H.D. Weiss, L. Marsh, Impulse control disorders and compulsive behaviours associated with dopaminergic therapies in Parkinson’s disease. Neurol. Clin. Pract. 2, 267–274 (2012)CrossRefPubMedPubMedCentralGoogle Scholar
  22. 22.
    A. Nevely, A. Frei, M. Graf, PO2-58: sexual misconduct induced by iatrogenic hyperprolactinaemia. Eur. Psychiatry 25, 678 (2010)CrossRefGoogle Scholar
  23. 23.
    T.J. Moore, J. Glenmullen, D.R. Mattison, Reports of pathological gambling, hypersexuality and compulsive shopping associated with dopamine receptor agonist drugs. JAMA Intern. Med. 174, 1930–1933 (2014)CrossRefPubMedGoogle Scholar
  24. 24.
    Joint Formulary Committee, British National Formulary, 68th edn. (BMJ Group and Pharmaceutical Press, London, 2015)Google Scholar
  25. 25.
    M. Davie, Pathological gambling associated with cabergoline therapy in a patient with a pituitary prolactinoma. J. Neuropsychiatry Clin. Neurosci. 19, 473–474 (2007)CrossRefPubMedGoogle Scholar
  26. 26.
    H. Falhammar, J.Y. Yarker, Pathological gambling and hypersexuality in cabergoline-treated prolactinoma. Med. J. Aust. 190, 97 (2009)PubMedGoogle Scholar
  27. 27.
    M. Gahr, B.J. Connemann, C.J. Schönfeldt-Lecuona, Pathological gambling induced by dopamine agonists. Fortschr. Neurol. Psychiatr. 79, 470–474 (2011)CrossRefPubMedGoogle Scholar
  28. 28.
    S.K. Thondam, S. Alusi, K. O’Driscoll, C.E. Gilkes, D.J. Cuthbertson, C. Daousi, Impulse control disorder in a patient on long-term treatment with bromocriptine for a macroprolactinoma. Clin. Neuropharmacol. 36, 170–172 (2013)CrossRefPubMedGoogle Scholar
  29. 29.
    A. Gupta, R.S. Zimmerman, Hypersexuality in cabergoline-treated prolactinoma, 93rd Annual Meeting of the Endocrine Society: abstr. P3-312, 2011Google Scholar
  30. 30.
    M.R. Nannenga, P.J. Tebben, T.B. Nippoldt, Development of impulse control disorders in patients with dopamine agonist-treated prolactinomas: a case series. 93rd Annual Meeting of the Endocrine Society: abstr. P3-311, 2011Google Scholar
  31. 31.
    J. Martinkova, L. Trejbalova, M. Sasikova, J. Benetin, P. Valkovic, Impulse control disorders associated with dopaminergic medication in patients with pituitary adenomas. Clin. Neuropharmacol. 34, 179–181 (2011)CrossRefPubMedGoogle Scholar
  32. 32.
    M.C. Viana, L.H. Andrade, Lifetime prevalence, age and gender distribution and age-of-onset of psychiatric disorders in the Sao Paolo metropolitan area, Brazil: results from Sao Paolo Megacity Mental Health Survey. Rev. Bras. Psiquiatr. 34, 249–260 (2012)CrossRefPubMedGoogle Scholar
  33. 33.
    M. Barake, A.E. Evins, L. Stoeckel, G.N. Pachas, L.B. Nachtigall, K.K. Miller, B.M. Biller, N.A. Tritos, A. Klibanski, Investigation of impulsivity in patients on dopamine agonist therapy for hyperprolactinemia: a pilot study. Pituitary 17, 150–156 (2014)CrossRefPubMedPubMedCentralGoogle Scholar
  34. 34.
    I. Bancos, M.R. Nannenga, J.M. Bostwick, M.H. Silber, D. Erickson, T.B. Nippoldt, Impulse control disorders in patients with dopamine agonist-treated prolactinomas and non-functioning pituitary adenomas: a case–control study. Clin. Endocrinol. 80, 863–868 (2014)CrossRefGoogle Scholar
  35. 35.
    A.P. Athanasoulia, M. Ising, H. Pfister, C.S. Mantzoros, G.K. Stalla, C. Sievers, Distinct dopaminergic personality patterns in patients with prolactinomas: a comparison with nonfunctioning pituitary adenoma patients and age- and gender-matched controls. Neuroendocrinology 96, 204–211 (2012)CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Sean Noronha
    • 1
  • Victoria Stokes
    • 1
    Email author
  • Niki Karavitaki
    • 1
  • Ashley Grossman
    • 1
  1. 1.Oxford Centre for Diabetes, Endocrinology and MetabolismUniversity of OxfordOxfordUK

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