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Endocrine

, Volume 53, Issue 2, pp 530–537 | Cite as

25-Hydroxyvitamin D insufficiency discriminates cardiovascular risk factors accumulation in peri-pubertal boys undergoing overweight screening

  • Andrea Di Nisio
  • Luca De Toni
  • Elvio D’Addato
  • Maria R. Pizzo
  • Pasquale Sabatino
  • Carlo ForestaEmail author
Original Article

Abstract

The aim of this study was to evaluate the possible association between cardiometabolic risk factors accumulation and vitamin D status in a cohort of Italian normal weight and overweight male children. 108 boys enrolled in an andrological health prevention project underwent physical examination, anthropometric measurements, and fasting blood sampling. Serum blood glucose, HDL-cholesterol, triglycerides, parathyroid hormone, and 25-hydroxyvitamin D (25(OH)D) were measured. Cardiovascular risk factors were defined according to the National Cholesterol Education Program Adult Treatment Panel III modified for age. Lean and overweight subjects differed in terms of waist circumference (P < 0.001), HDL-cholesterol (P = 0.001), triglycerides (P = 0.001), systolic blood pressure (P < 0.001) and diastolic blood pressure (P = 0.002). Both groups had similar mean 25(OH)D levels (P = 0.160) and were below the sufficiency threshold: indeed only 24 % of normal weight had 25(OH)D ≥30 ng/ml, and even less in the overweight/obese group (8 %, P = 0.03 vs. normal weight). A significant accumulation of risk factors in course of 25(OH)D insufficiency was detected in both the whole cohort and in the normal weight group (P = 0.003 and P = 0.04, respectively) with odd ratios of 1.31 (1.16–1.49 95%CI) and 1.41 (1.18–1.69 95%CI), respectively. In course of vitamin D deficiency, the odd ratios were 2.24 (1.34–3.77 95%CI, P = 0.003) in the whole cohort and 2.40 (1.27–4.82 95%CI, P = 0.03) in lean subjects. We reported a considerable occurrence of cardiovascular risk factors in course of hypovitaminosis D in overweight/obese boys and even in lean subjects, which normally would not have been further evaluated by considering the sole BMI-related parameters. In this regard, 25(OH)D levels appear as a potential discriminating parameter able to identify male children at higher health risk.

Keywords

Vitamin D Children Obesity Adolescents Cardiovascular risk Metabolic syndrome 

Notes

Author Contribution

ADN, LDT, and CF wrote the manuscript, EDA, PS collected the data, MRP performed laboratory assessment, ADN analyzed the data.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest and financial relationships with any organizations that might have an interest in the submitted work. No external funding has been secured for this study.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Supplementary material

12020_2015_725_MOESM1_ESM.doc (30 kb)
Supplementary material 1 (DOC 30 kb)
12020_2015_725_MOESM2_ESM.ppt (101 kb)
Supplementary material 2 (PPT 101 kb)

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Andrea Di Nisio
    • 1
  • Luca De Toni
    • 1
  • Elvio D’Addato
    • 2
  • Maria R. Pizzo
    • 2
  • Pasquale Sabatino
    • 3
  • Carlo Foresta
    • 1
    Email author
  1. 1.Department of Medicine, Unit of Andrology and Human Reproductive MedicineUniversity of PadovaPaduaItaly
  2. 2.U.O. Medicina P.O.Sapri (Salerno)Italy
  3. 3.Asl Salerno and Asl Napoli 3/sudSalernoItaly

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