, Volume 50, Issue 2, pp 297–305 | Cite as

PET imaging in ectopic Cushing syndrome: a systematic review

  • Prasanna Santhanam
  • David Taieb
  • Luca Giovanella
  • Giorgio Treglia


Cushing syndrome due to endogenous hypercortisolism may cause significant morbidity and mortality. The source of excess cortisol may be adrenal, pituitary, or ectopic. Ectopic Cushing syndrome is sometimes difficult to localize on conventional imaging like CT and MRI. After performing a multilevel thoracoabdominal imaging with CT, the evidence regarding the use of radiotracers for PET imaging is unclear due to significant molecular and etiological heterogeneity of potential causes of ectopic Cushing’s syndrome. In our systematic review of literature, it appears that GalLium-based (Ga68) somatostatin receptor analogs have better sensitivity in diagnosis of bronchial carcinoids causing Cushing syndrome and FDG PET appears superior for small-cell lung cancers and other aggressive tumors. Further large-scale studies are needed to identify the best PET tracer for this condition.


PET Ectopic Cushing syndrome 18F-FDG Octreoscan 


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Prasanna Santhanam
    • 1
  • David Taieb
    • 2
    • 3
  • Luca Giovanella
    • 4
  • Giorgio Treglia
    • 4
  1. 1.Section of Endocrinology, Department of Internal Medicine, Joan C Edwards School of MedicineMarshall UniversityHuntingtonUSA
  2. 2.Department of Nuclear Medicine, La Timone University Hospital, CERIMEDAix-Marseille UniversityMarseilleFrance
  3. 3.Marseille Cancerology Research CenterInstitut Paoli-CalmettesMarseilleFrance
  4. 4.Nuclear Medicine and PET/CT CenterOncology Institute of Southern SwitzerlandBellinzona and LuganoSwitzerland

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