, Volume 48, Issue 2, pp 371–393

Prediabetes and associated disorders

  • Martin Buysschaert
  • José Luís Medina
  • Michael Bergman
  • Avni Shah
  • Jaqueline Lonier

DOI: 10.1007/s12020-014-0436-2

Cite this article as:
Buysschaert, M., Medina, J.L., Bergman, M. et al. Endocrine (2015) 48: 371. doi:10.1007/s12020-014-0436-2


Prediabetes represents an elevation of plasma glucose above the normal range but below that of clinical diabetes. Prediabetes includes individuals with IFG, IGT, IFG with IGT and elevated HbA1c levels. Insulin resistance and β-cell dysfunction are characteristic of this disorder. The diagnosis of prediabetesis is vital as both IFG and IGT are indeed well-known risk factors for type 2 diabetes with a greater risk in the presence of combined IFG and IGT. Furthermore, as will be illustrated in this review, prediabetes is associated with associated disorders typically only considered in with established diabetes. These include cardiovascular disease, periodontal disease, cognitive dysfunction, microvascular disease, blood pressure abnormalities, obstructive sleep apnea, low testosterone, metabolic syndrome, various biomarkers, fatty liver disease, and cancer. As the vast majority of individuals with prediabetes are unaware of their diagnosis, it is therefore vital that the associated conditions are identified, particularly in the presence of mild hyperglycemia, so they may benefit from early intervention.


Prediabetes Cardiovascular disease Testosterone deficiency Cognitive dysfunction Nonalcoholic fatty liver disease Cancer 

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Martin Buysschaert
    • 1
  • José Luís Medina
    • 2
  • Michael Bergman
    • 3
  • Avni Shah
    • 4
  • Jaqueline Lonier
    • 5
  1. 1.Department of Endocrinology and DiabetologyUniversity Clinic Saint-Luc, Université Catholique de LouvainBrusselsBelgium
  2. 2.Oporto Medical SchoolOporto UniversityOportoPortugal
  3. 3.Division of Endocrinology and MetabolismNYU Diabetes and Endocrine Associates, NYU School of MedicineNew YorkUSA
  4. 4.Internal MedicineSouth Shore HospitalWeymouthUSA
  5. 5.Endocrinology, Diabetes and MetabolismNYU School of MedicineNew YorkUSA

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