Endocrine

, Volume 49, Issue 1, pp 70–77 | Cite as

Diagnostic values of thyroglobulin measurement in fine-needle aspiration of lymph nodes in patients with thyroid cancer

  • Kyoungjune Pak
  • Sunghwan Suh
  • Hyunsook Hong
  • Gi Jeong Cheon
  • Seo Kyung Hahn
  • Keon Wook Kang
  • E. Edmund Kim
  • Dong Soo Lee
  • June-Key Chung
Meta-Analysis
First Online:
Received:
Accepted:

Abstract

We aimed to evaluate the diagnostic performance of measuring the concentration of thyroglobulin (Tg) in the washout fluid of the needle aspiration (FNA-Tg). We performed a systematic search of MEDLINE (inception to October 2013) and EMBASE (inception to October 2013) for English publications using keywords “thyroid”, “aspiration”, “washout”, and “thyroglobulin”. All searches were limited to human studies. We included studies of FNA-Tg measurement in the washout fluid rinsed with 1 ml of normal saline. Eight studies including 843 lymph nodes (LNs) were eligible for this study. The pooled sensitivity and specificity of preoperative studies are 0.89 [95 % CI 0.82–0.95], 0.60 [0.49–0.70], and those of postoperative studies are 1.0 [0.83–1.0], 1.0 [0.92–1.0]. To determine best cutoffs from each preoperative and postoperative study, the distance between the point (0, 1) and each observed cutoff values (1-specificity, sensitivity) was calculated, and the distance is minimal when the cutoff value of 32.04 for preoperative studies and of 0.9 for postoperative one are selected. FNA-Tg can be used for both preoperative and postoperative evaluation of LN metastasis. Although the cutoff values for the FNA-Tg has not been standardized, preoperative values of 32.04 ng/ml and postoperative values of 0.9 ng/ml are recommended for identifying neck LN metastasis

Keywords

Thyroid cancer Biopsy Fine-needle Thyroglobulin 
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Notes

Acknowledgments

This work was supported by the National Research Foundation of Korea (NRF) Grant for the Global Core Research Center (GCRC) funded by the Korea government (Ministry of Science, ICT & Future Planning:MSIP) (No. 2011-0030680).

Conflict of interest

Nothing to declare.

Supplementary material

12020_2014_410_MOESM1_ESM.tif (319 kb)
Supplementary material 1 (TIFF 319 kb)

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Kyoungjune Pak
    • 1
    • 2
  • Sunghwan Suh
    • 3
  • Hyunsook Hong
    • 4
  • Gi Jeong Cheon
    • 1
    • 5
  • Seo Kyung Hahn
    • 4
  • Keon Wook Kang
    • 1
    • 5
  • E. Edmund Kim
    • 6
    • 7
  • Dong Soo Lee
    • 1
    • 5
    • 6
  • June-Key Chung
    • 1
    • 5
  1. 1.Department of Nuclear MedicineSeoul National University College of MedicineSeoulSouth Korea
  2. 2.Department of Nuclear MedicinePusan National University HospitalBusanSouth Korea
  3. 3.Department of Internal MedicineDong-A University College of MedicineBusanSouth Korea
  4. 4.Medical Research Collaborating CenterSeoul National University College of MedicineSeoulSouth Korea
  5. 5.Cancer Research InstituteSeoul National University College of MedicineSeoulSouth Korea
  6. 6.WCU Graduate School of Concergence Science and TechnologySeoul National University College of MedicineSeoulSouth Korea
  7. 7.Department of Radiological ScienceUniversity of California at IrvineCAUSA

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