, Volume 48, Issue 3, pp 1005–1009 | Cite as

The effect of anagliptin treatment on glucose metabolism and lipid metabolism, and oxidative stress in fasting and postprandial states using a test meal in Japanese men with type 2 diabetes

  • Hirokazu Kakuda
  • Junji KobayashiEmail author
  • Masahiro Kakuda
  • Junichi Yamakawa
  • Noboru Takekoshi
Research Letter

It has been generally recognized that postprandial hyperglycemia and hyperlipidemia are highly related to the development of atherosclerosis [1, 2]. Hyperglycemia is known to damage vascular endothelial cells, increase oxidative stress, promote the expression of adhesion molecule and inhibit nitric oxide (NO) production [3]. Remnant lipoprotein, an important component of postprandial hyperlipidemia, promotes foam cell formation of macrophages and proliferation of smooth muscle cells [4]. Dipeptidyl peptidase 4 (DPP-4) inhibitors have attracted attention as a new class of anti-diabetic agents for the treatment of type 2 diabetes [5]. Anagliptin, a member of the medication class of DPP-4 inhibitors, has been recently available in the market in Japan. Animal studies suggest that anagliptin treatment is associated with improvement of glucose tolerance either by amelioration of insulin resistance or enhancing insulin secretion [6] and the decrease in the development of atherosclerosis [7]....


Anagliptin Test meal Adiponectin Remnant Renal function 8-OHdG 


Conflict of interest

There is no conflict of interest for all of the authors regarding this work.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Hirokazu Kakuda
    • 1
  • Junji Kobayashi
    • 2
    Email author
  • Masahiro Kakuda
    • 1
  • Junichi Yamakawa
    • 2
  • Noboru Takekoshi
    • 3
  1. 1.Kakuda ClinicKahokuJapan
  2. 2.Department of General MedicineKanazawa Medical UniversityKahokuJapan
  3. 3.Kanazawa Medical UniversityKazhokuJapan

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