Endocrine

, Volume 46, Issue 1, pp 16–28 | Cite as

Implications of adiponectin in linking metabolism to testicular function

Review
First Online:
Received:
Accepted:

Abstract

Obesity is a major health problem, contributing to the development of various diseases with aging. In humans, obesity has been associated with reduced testosterone production and subfertility. Adipose tissue is an important source of hormones having influences on both metabolism and reproduction. Among them, the production and secretion of adiponectin is inversely correlated to the severity of obesity. The purpose of this review of literature is to present the current state of knowledge on adiponectin research to determine whether this hormone affects reproduction in men. Surprisingly, evidences show negative influences of adiponectin on GnRH secretion from the hypothalamus, LH and FSH secretion from the pituitary and testosterone at the testicular level. Thus far, the involvement of adiponectin in the influence of metabolism on reproduction in men is limited. However, adiponectin and its receptors are expressed by different cell types of the male gonad, including Leydig cells, spermatozoa, and epididymis. In addition, actions of adiponectin at the testicular level have been shown to promote spermatogenesis and sperm maturation. Therefore, autocrine/paracrine actions of adiponectin in the testis may contribute to support male reproductive function.

Keywords

Adiponectin Testis Leydig cells Sertoli cells Spermatogenesis Steroidogenesis 
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Notes

Acknowledgments

Current work was funded by the New Brunswick Health Research Foundation (NBHRF), Canada.

Disclosure

The author declares that there is no conflict of interest that would prejudice his impartiality.

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© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Biology DepartmentUniversité de MonctonMonctonCanada

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