, Volume 44, Issue 1, pp 200–206 | Cite as

Left ventricular synchronicity is impaired in patients with active acromegaly

  • Abdulkadir KırışEmail author
  • Cihangir Erem
  • Oğuzhan Ekrem Turan
  • Nadim Civan
  • Gülhanım Kırış
  • İrfan Nuhoğlu
  • Abdulselam İlter
  • Halil Önder Ersöz
  • Merih Kutlu
Original Article


Acromegaly is associated with a variety of cardiovascular disturbances such as left ventricular hypertrophy, diastolic cardiac dysfunction, and hypertension. Left ventricular (LV) dyssynchrony means the impairment of synchronicity and is defined as the loss of the simultaneous peak contraction of corresponding cardiac segments. The objective of this study was to investigate whether acromegalic patients have left ventricular dyssynchrony. Dyssynchrony was evaluated in 30 patients with active acromegaly and 30 controls. All the patients and controls were subjected to a tissue synchronization imaging. The time to regional peak systolic tissue velocity (Ts) in LV by the six-basal-six-mid-segmental model was measured on ejection phase TSI images and four TSI parameters of systolic dyssynchrony were computed. All TSI parameters of LV dyssynchrony increased in patients with acromegaly compared to the controls: the standard deviation (SD) of the 12 LV segments Ts (43.5 ± 13.5 vs 26.2 ± 12.5, p < 0.001); the maximal difference in Ts between any 2 of the 12 LV segments (133.3 ± 38 vs 84.6 ± 37.6, p < 0.001); the SD of the 6 basal LV segments (41.1 ± 15.9 vs 25.4 ± 14.8, p = 0.001); and the maximal difference in Ts between any 2 of the 6 basal LV segments (102.6 ± 37.5 vs 65.2 ± 36.9, p = 0.001). In addition, there were significant relationships between the levels of growth hormone/insulin-like growth factor-1 and Ts-SD-12. LV synchronicity has been impaired in patients with acromegaly. Left ventricular dyssynchrony is associated with disease activity and it may contribute to the harmful cardiovascular effects of acromegaly.


Acromegaly Growth hormone Left ventricular dyssynchrony Tissue synchronization imaging 


Conflict of interest



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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Abdulkadir Kırış
    • 1
    Email author
  • Cihangir Erem
    • 2
  • Oğuzhan Ekrem Turan
    • 1
  • Nadim Civan
    • 2
  • Gülhanım Kırış
    • 3
  • İrfan Nuhoğlu
    • 2
  • Abdulselam İlter
    • 1
  • Halil Önder Ersöz
    • 2
  • Merih Kutlu
    • 1
  1. 1.Department of Cardiology, Faculty of MedicineKaradeniz Technical UniversityTrabzonTurkey
  2. 2.Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of MedicineKaradeniz Technical UniversityTrabzonTurkey
  3. 3.Department of CardiologyAhi Evren Cardiovascular and Thoracic Surgery Training and Research HospitalTrabzonTurkey

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