, Volume 43, Issue 3, pp 564–570

Resistance training decreases serum inflammatory markers in diabetic rats

Original Article

DOI: 10.1007/s12020-012-9786-9

Cite this article as:
Talebi-Garakani, E. & Safarzade, A. Endocrine (2013) 43: 564. doi:10.1007/s12020-012-9786-9


Inflammation plays an important role in the genesis and progression of diabetes. The purpose of this study was to investigate the effect of resistance training on serum levels of some inflammatory markers associated with diabetes mellitus. Twenty-four male Wistar rats (290 ± 19 g) were randomly divided into three groups: non-diabetic control (non-DC), diabetic control (DC), and diabetic trained (DT). Animals in DT group were subjected to a resistance training program with the use of a ladder (3 days/week, for 4 weeks). Body weight, serum high sensitivity C-reactive protein (hs-CRP), interleukin (IL)-6, tumor necrosis factor (TNF)-α, fasting glucose, and insulin were measured. Four weeks of resistance training decreased serum levels of TNF-α, hs-CRP, and IL-6 in diabetic rats when compared with DC animals. We conclude that resistance training with appropriate intensity, duration, and recovery between exercise bouts has marked anti-inflammatory effects on diabetic rats. This may be an efficient strategy to protect against some diabetic complications.


Diabetes mellitus Resistance training IL-6 TNF-α hs-CRP 

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Exercise Physiology, Faculty of Physical Education & Sport ScienceUniversity of MazandaranBabolsarIran

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