Ghrelin concentrations in maternal and cord blood of Type 1 diabetic and non-diabetic pregnancies at term
Pre-existing Type 1 Diabetes mellitus (T1DM) complicates 1–2 % of all pregnancies and is associated with increased perinatal morbidity and mortality [1, 2]. The risk of congenital malformations, polyhydramnios, pre-term delivery, pre-eclampsia, caesarean delivery, and fetal macrosomia (large for dates infant) are increased compared with non-diabetic pregnancies. Even amongst pre-gestational diabetic women with antenatal normoglycaemia, the risk of macrosomia and perinatal complications is still increased .
Ghrelin is a 28-amino acid peptide and is the endogenous ligand for the growth hormone secretagogue receptor. It is involved in the control of food intake, energy balance, and utilisation of fat during pregnancy . Ghrelin belongs to a group called the adipocytokines, which also includes leptin, and have functions in appetite and satiety but have also been shown to play integral roles in fetal growth and development .
Ghrelin is synthesised primarily in the...
KeywordsGlycaemic Control Fetal Growth Ghrelin Level Diabetic Mother Ghrelin Concentration
Conflict of interest
The authors declare no conflict of interest.
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