Endocrine

, Volume 43, Issue 1, pp 127–135 | Cite as

The influence of the genetic and non-genetic factors on bone mineral density and osteoporotic fractures in Chinese women

  • Yan-Hua Deng
  • Lin Zhao
  • Min-Jia Zhang
  • Chun-Ming Pan
  • Shuang-Xia Zhao
  • Hong-Yan Zhao
  • Li-Hao Sun
  • Bei Tao
  • Huai-Dong Song
  • Wei-Qing Wang
  • Guang Ning
  • Jian-Min Liu
Original Article

Abstract

To investigate the effects of genetic and non-genetic factors on bone mineral densities (BMDs) and osteoporotic fractures. This was a cross-sectional study to investigate the relationships between 18 SNPs and non-genetic factors with BMDs and osteoporotic fractures in 1012 Chinese Han women. Five SNPs in genes GPR177, CTNNB1, MEF2C, SOX6, and TNFRSF11B were associated with L1-4 or total hip BMDs. rs11898505 in SPTBN1 gene was associated with osteoporotic fractures. Subjects carrying the largest number of risk alleles (highest 10 %) not only had lower BMD values as compared to those carrying the least number of risk alleles (lowest 10 %), they also had a higher risk of fracture [P = 0.002, OR = 2.252, 95 %CI (1.136, 4.463)]. Results from multivariate stepwise regression analysis revealed that age [P < 0.001, OR = 1.038, 95 % CI (1.018, 1.058)], number of falls in a year [P < 0.001, OR = 2.347, 95 % CI (1.459, 3.774)], the G risk allele in rs11898505 [P = 0.023, OR = 1.559, 95 % CI (1.062, 2.290)], and the L1-4 BMD [P = 0.017, OR = 0.286, 95 % CI (0.102, 0.798)] were associated with the occurrence of osteoporotic fractures. Genetic (rs11898505) and non-genetic factors (age, number of falls in a year and L1-4 BMD) could work in concert to contribute to the risk of osteoporotic fractures.

Keywords

Genetic factors Non-genetic factors BMD Osteoporosis Osteoporotic fractures 

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Yan-Hua Deng
    • 1
  • Lin Zhao
    • 1
  • Min-Jia Zhang
    • 1
  • Chun-Ming Pan
    • 2
  • Shuang-Xia Zhao
    • 2
  • Hong-Yan Zhao
    • 1
  • Li-Hao Sun
    • 1
  • Bei Tao
    • 1
  • Huai-Dong Song
    • 2
  • Wei-Qing Wang
    • 1
  • Guang Ning
    • 1
  • Jian-Min Liu
    • 1
  1. 1.Department of Endocrine and Metabolic DiseasesRui-jin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Endocrine and Metabolic Division of Shanghai Universities E-InstitutesShanghaiPeople’s Republic of China
  2. 2.State Key Laboratory of Medical Genomics, Molecular Medicine Center, Rui-jin HospitalShanghai Jiao-tong University School of MedicineShanghaiPeople’s Republic of China

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