, Volume 42, Issue 3, pp 694–699

Nesfatin-1 and other hormone alterations in polycystic ovary syndrome

  • Rulin Deniz
  • Bilgin Gurates
  • Suleyman Aydin
  • Husnu Celik
  • İbrahim Sahin
  • Yakup Baykus
  • Zekiye Catak
  • Aziz Aksoy
  • Cihan Citil
  • Sami Gungor
Original Article


Polycystic ovary syndrome (PCOS) is commonly characterised by obesity, insulin resistance (IR), hyperandrogenemia and hirsutism. Nesfatin-1 a recently discovered hormone, acts upon energy balance, glucose metabolism, obesity and probably gonadal functions. This study was to evaluate the circulating levels of nesfatin-1 in patients with PCOS (n = 30) and in age and body mass index (BMI)-matched controls (n = 30). PCOS patients had significantly lower levels of nesfatin-1 (0.88 ± 0.36 ng/mL) than healthy controls (2.22 ± 1.14 ng/mL). PCOS patients also had higher gonadotropin and androgen plasma concentrations, Ferriman–Gallwey scores, blood glucose levels and a homeostasis model of assessment-IR index (HOMA-IR) index than in healthy women. Correlation tests in PCOS subjects detected a negative correlation between nesfatin-1 levels and BMI, fasting blood glucose, insulin levels and a HOMA-IR index. Lower nesfatin-1 concentration may plays a very important role in the development of PCOS.


PCOS Nesfatin-1 Ferriman–Gallwey scores 



17 Alpha hydroxyprogesterone




Body mass index


Cerebrospinal fluid


Coefficient of variance


Dehydroepiandrosterone sulphate


Diabetes mellitus




Ethylenediaminetetraacetic acid


Fatty acid binding protein


Fasting blood glucose




Follicle-stimulating hormone


Fasting serum insulin


High density lipoprotein


Homeostasis model of assessment-insulin resistance index


Insulin-like growth factor


Insulin resistance


Kallikrein inactivation unit


Low density lipoprotein


Luteinizing hormone


Last menstrual date


Polycystic ovary syndrome




Sex-hormone binding globulin


Thyroid-stimulating hormone


Total testosterone


Very low density lipoprotein


Waist-hip circumference ratio


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Rulin Deniz
    • 1
  • Bilgin Gurates
    • 1
  • Suleyman Aydin
    • 2
  • Husnu Celik
    • 1
  • İbrahim Sahin
    • 3
  • Yakup Baykus
    • 1
  • Zekiye Catak
    • 2
  • Aziz Aksoy
    • 4
  • Cihan Citil
    • 5
  • Sami Gungor
    • 1
  1. 1.Department of Obstetrics and GynecologyFirat University HospitalElazigTurkey
  2. 2.Department of Medical Biochemistry and Clinical Biochemistry, Firat Hormones Research GroupFirat University HospitalElazigTurkey
  3. 3.Department of Nutrition and DieteticsErzincan UniversityErzincanTurkey
  4. 4.Department of Nutrition and DieteticsBitlis Eren UniversityBitlisTurkey
  5. 5.Department of Biological ScienceFirat UniversityElazigTurkey

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