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Role of biological targeted therapies in gastroenteropancreatic neuroendocrine tumours

Mini Review


Approximately two-thirds of neuroendocrine tumours (NET) occur in the gastrointestinal tract and over 60% present with metastases. With greater insight into molecular pathways involved in tumour progression, opportunities are presented for the use of targeted therapies in NET. Although a wide array of targeted agents has been investigated, only a handful has emerged as forerunners from recent clinical trials. This literature review focuses on the use of anti-angiogenic monoclonal antibody bevacizumab, as well as small molecule inhibitors sunitinib and everolimus.


Bevacizumab Carcinoid Everolimus Neuroendocrine Pancreatic Sunitinib 



NHS funding to the NIHR Biomedical Research Centre is acknowledged.

Conflict of interest

The author has no conflict of interest to declare.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Gastrointestinal Cancer and Lymphoma Research UnitThe Royal Marsden NHS Foundation TrustLondon, SurreyUK

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