Clinical characteristics of fulminant type 1 diabetes associated with pregnancy in China
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To report 12 cases of pregnancy-associated fulminant type 1 diabetes mellitus (PF) found in China from 2003 to 2010. The clinical and biochemical characteristics of these cases with PF were compared with a group of cases of child-bearing age with fulminant type 1 diabetes that was not associated with pregnancy (NPF). The clinical and biochemical characteristics of 12 PF cases were analyzed retrospectively and then compared with those characteristics of 20 NPF cases in China. The difference between Chinese and Japanese PF cases was investigated. The mean values of the characteristics from PF and NPF cases in China, including postprandial serum C-peptide concentration, plasma glucose concentration, and serum chloride were different. Compared to the 22 PF cases in Japan, the mean age of these 12 PF cases was much younger. The mean fasting and postprandial serum C-peptide concentration level were lower, and the mean HbA1c levels was higher in 12 PF cases in China. Eight of 12 PF cases in China developed the disease during pregnancy. Other four PF case developed the disease within 2 weeks after delivery. 12 PF cases in China showed more severe beta-cell destruction, the prognosis of their fetuses was extremely poor.
KeywordsFulminant Type 1 diabetes Pregnancy China
We would like to thank the following hospitals: Hangzhou First People Hospital, Dalian Forth People Hospital, Chinese National Petroleum East Corporation Center Hospital, Nanjing Medical University First Hospital, Sun Yat-sen University Third Hospital, Kaohsiung Medical University Hospital, Zhejiang University School of Medicine Affiliated Sir Run Run Shaw Hospital, Hebei Xuanhua General Staff Communication Training Base Hospital, Zunyi Medical College Hospital, Shanghai Jiaotong University Affi1iated Sixth People Hospital, General Hospital of Tianjin Dagang Oilfield, Peking Union Medical College Hospital, Guangxi Medical University First Hospital, Sun Yat-sen University Bo Ji Hospital, Ningbo Beilun People Hospital, Fudan University Hua Shan Hospital, Xuzhou Medical College Hospital, Weifang Medical College Hospital, Inner Mongolia Medical College Hospital, Xi’an Jiaotong University First Hospital.
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