Endocrine

, Volume 40, Issue 1, pp 84–89

Health-related quality of life and fatigue in patients with adrenal incidentaloma

  • Darko Kastelan
  • Fedja Dzubur
  • Tina Dusek
  • Tamara Poljicanin
  • Zeljka Crncevic-Orlic
  • Ivana Kraljevic
  • Mirsala Solak
  • Tanja Bencevic
  • Izet Aganovic
  • Nikola Knezevic
  • Zeljko Kastelan
  • Mirko Korsic
Original Article

Abstract

The objective of the present study was to examine several dimensions of quality of life (QoL) and fatigue in patients with adrenal incidentaloma. This was a case–control study designed to analyze patient outcomes using three validated generic QoL questionnaires, EQ-5D, SF-36, and MFI-20, the results of which were compared to those obtained for age- and sex-matched controls. The study population comprised 139 consecutive patients with nonfunctioning adrenal masses (104 females, 35 males; age 59.1 ± 10.8) and 139 age- and sex-matched controls. Reduced QoL was found in patients with adrenal incidentaloma as compared to controls. Dimensions of QoL that were notably affected included mobility (P = 0.03), performance of usual activities (P = 0.002), and anxiety/depression (P = 0.04) as evaluated using the EQ-5D; physical functioning (P < 0.001), physical role (P < 0.001), general health (P < 0.001), vitality (P = 0.001), social functioning (P = 0.001), and emotional role (P < 0.001) as evaluated using the SF-36; and physical fatigue (P = 0.04) as assessed using the MFI-20 questionnaire. In addition, perceived health on a visual analogue scale was also significantly lower in patients than in controls (64.8 ± 19.2 vs. 77.1 ± 15.1; P < 0.001). Patients with adrenal incidentaloma reported reduced QoL and a higher level of physical fatigue compared to age- and sex-matched controls. This subject will benefit from further studies comparing QoL outcomes of laparoscopic adrenalectomy versus no treatment in patients with adrenal incidentaloma.

Keywords

Adrenal incidentaloma Quality of life Subclinical Cushing’s syndrome EQ-5D SF-36 MFI-20 

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Darko Kastelan
    • 1
    • 2
  • Fedja Dzubur
    • 2
  • Tina Dusek
    • 1
    • 2
  • Tamara Poljicanin
    • 3
  • Zeljka Crncevic-Orlic
    • 4
  • Ivana Kraljevic
    • 2
  • Mirsala Solak
    • 5
  • Tanja Bencevic
    • 1
  • Izet Aganovic
    • 1
    • 2
  • Nikola Knezevic
    • 6
  • Zeljko Kastelan
    • 1
    • 6
  • Mirko Korsic
    • 1
    • 2
  1. 1.School of MedicineUniversity of ZagrebZagrebCroatia
  2. 2.Department of EndocrinologyUniversity Hospital ZagrebZagrebCroatia
  3. 3.Vuk Vrhovac University Clinic for Diabetes, Endocrinology and Metabolic DiseasesZagrebCroatia
  4. 4.Department of EndocrinologyUniversity Hospital RijekaRijekaCroatia
  5. 5.University Hospital for Pulmonary DiseasesZagrebCroatia
  6. 6.Department of UrologyUniversity Hospital ZagrebZagrebCroatia

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