Advertisement

Endocrine

, Volume 39, Issue 3, pp 205–211 | Cite as

Biological effects of obestatin

  • Jiang-Bo Li
  • Akihiro Asakawa
  • KaiChun Cheng
  • Yingxiao Li
  • Huhe Chaolu
  • Minglun Tsai
  • Akio Inui
Review

Abstract

Obestatin, a 23-amino-acid peptide, is derived from the preproghrelin precursor. Obestatin was identified in 2005 as a hormone regulating food intake and energy, and having opposite effects to those of ghrelin. However, as studies have progressed, many disputes on the physiological function of obestatin have emerged. The food intake suppressive effects of obestatin have not been replicated in many studies. Nonetheless, many biological roles of obestatin have been revealed, and obestatin is thought to be associated with a variety of biological functions such as feeding, drinking, incretion, memory, and sleep, and with neuropsychiatric manifestations. The biological effects of obestatin will be reviewed in this article.

Keywords

Obestatin GPR39 Acylated ghrelin Des-acyl ghrelin Biological effects 

References

  1. 1.
    Y. Zhang, R. Proenca, M. Maffei, M. Barone, L. Leopold, J.M. Friedman, Nature 372, 425 (1994)PubMedCrossRefGoogle Scholar
  2. 2.
    L.A. Campfield, F.J. Smith, P. Burn, Horm. Metab. Res. 28, 619 (1996)PubMedCrossRefGoogle Scholar
  3. 3.
    A.D. Howard, S.D. Feighner, D.F. Cully, J.P. Arena, P.A. Liberator, C.I. Rosenblum, M. Hamelin, D.L. Hreniuk, O.C. Palyha, J. Anderson, P.S. Paress, C. Diaz, M. Chou, K.K. Liu, K.K. McKee, S.S. Pong, L.Y. Chaung, A. Elbrecht, M. Dashkevicz, R. Heavens, M. Rigby, D.J. Sirinathsinghji, D.C. Dean, D.G. Melillo, A.A. Patchett, R. Nargund, P.R. Griffin, J.A. DeMartino, S.K. Gupta, J.M. Schaeffer, R.G. Smith, L.H. Van der Ploeg, Science 273, 974 (1996)PubMedCrossRefGoogle Scholar
  4. 4.
    M. Kojima, H. Hosoda, Y. Date, M. Nakazato, H. Matsuo, K. Kangawa, Nature 402, 656 (1999)PubMedCrossRefGoogle Scholar
  5. 5.
    C.Y. Chen, A. Asakawa, M. Fujimiya, S.D. Lee, A. Inui, Pharmacol. Rev. 61, 430 (2009)PubMedCrossRefGoogle Scholar
  6. 6.
    J.B. Soares, A.F. Leite-Moreira, Peptides 29, 1255 (2008)PubMedCrossRefGoogle Scholar
  7. 7.
    M. Nakazato, N. Murakami, Y. Date, M. Kojima, H. Matsuo, K. Kangawa, S. Matsukura, Nature 409, 194 (2001)PubMedCrossRefGoogle Scholar
  8. 8.
    V.P. Carlini, M.E. Monzón, M.M. Varas, A.B. Cragnolini, H.B. Schiöth, T.N. Scimonelli, S.R. de Barioglio, Biochem. Biophys. Res. Commun. 299, 739 (2002)PubMedCrossRefGoogle Scholar
  9. 9.
    A. Asakawa, A. Inui, T. Kaga, H. Yuzuriha, T. Nagata, M. Fujimiya, G. Katsuura, S. Makino, M.A. Fujino, M. Kasuga, Neuroendocrinology 74, 143 (2001)PubMedCrossRefGoogle Scholar
  10. 10.
    G. Baldanzi, N. Filigheddu, S. Cutrupi, F. Catapano, S. Bonissoni, A. Fubini, D. Malan, G. Baj, R. Granata, F. Broglio, M. Papotti, N. Surico, F. Bussolino, J. Isgaard, R. Deghenghi, F. Sinigaglia, M. Prat, G. Muccioli, E. Ghigo, A. Graziani, J. Cell Biol. 159, 1029 (2002)PubMedCrossRefGoogle Scholar
  11. 11.
    H. Hosoda, M. Kojima, H. Matsuo, K. Kangawa, Biochem. Biophys. Res. Commun. 279, 909 (2000)PubMedCrossRefGoogle Scholar
  12. 12.
    C.Y. Chen, A. Imui, A. Asakawa, K. Fujino, I. Kato, C.C. Chen, N. Ueno, M. Fujimiya, Gastroenterology 129, 8 (2005)PubMedCrossRefGoogle Scholar
  13. 13.
    A. Asakawa, A. Inui, M. Fujimiya, R. Sakamaki, N. Shinfuku, Y. Ueta, M.M. Meguid, M. Kasuga, Gut 54, 18 (2005)PubMedCrossRefGoogle Scholar
  14. 14.
    J.V. Zhang, P.G. Ren, O. Avsian-Kretchmer, C.W. Luo, R. Rauch, C. Klein, A.J. Hsueh, Science 310, 996 (2005)PubMedCrossRefGoogle Scholar
  15. 15.
    J.P. Chanoine, A.C. Wong, V. Barrios, Horm. Res. 66, 81 (2006)PubMedCrossRefGoogle Scholar
  16. 16.
    A.J. Ren, Z.F. Guo, Y.K. Wang, L. Lin, X. Zheng, W.J. Yuan, Peptides 30, 439 (2009)PubMedCrossRefGoogle Scholar
  17. 17.
    S. Aydin, Y. Ozkan, F. Erman, B. Gurates, N. Kilic, R. Colak, T. Gundogan, Z. Catak, M. Bozkurt, O. Akin, Y. Sen, I. Sahn, Nutrition 24, 689 (2008)PubMedCrossRefGoogle Scholar
  18. 18.
    S.L. Dun, G.C. Brailoiu, E. Brailoiu, J. Yang, J.K. Chang, N.J. Dun, J. Endocrinol. 191, 481 (2006)PubMedCrossRefGoogle Scholar
  19. 19.
    E. Dag, S. Aydin, Y. Ozkan, F. Erman, A.F. Dagli, M. Gurger, Peptides 31, 932 (2010)PubMedCrossRefGoogle Scholar
  20. 20.
    P. Zizzari, R. Longchamps, J. Epelbaum, M.T. Bluet-Pajot, Endocrinology 148, 1648 (2007)PubMedCrossRefGoogle Scholar
  21. 21.
    H. Zamrazilová, V. Hainer, D. Sedlácková, H. Papezová, M. Kunesová, F. Bellisle, M. Hill, J. Nedvídková, Physiol. Res. 57(Suppl. 1), S49 (2008)PubMedGoogle Scholar
  22. 22.
    D. Mafra, F. Guebre-Egziabher, C. Cleaud, W. Arkouche, A. Mialon, J. Drai, D. Fouque, Obestatin and ghrelin interplay in hemodialysis patients. Nutrition. 2009;15 [Epub ahead of print]Google Scholar
  23. 23.
    F. Lippl, J. Erdmann, N. Lichter, S. Tholl, S. Wagenpfeil, O. Adam, V. Schusdziarra, Horm. Metab. Res. 40, 806 (2008)PubMedCrossRefGoogle Scholar
  24. 24.
    M.S. Mondal, K. Toshinai, H. Ueno, K. Koshinaka, M. Nakazato, J. Endocrinol. 198, 339 (2008)PubMedCrossRefGoogle Scholar
  25. 25.
    M.G. Morash, J. Gagnon, S. Nelson, Y. Anini, Tissue distribution and effects of fasting and obesity on the ghrelin axis in mice. Regul. Pept. 2010 Mar 30. [Epub ahead of print]Google Scholar
  26. 26.
    K.K. McKee, C.P. Tan, O.C. Palyha, J. Liu, S.D. Feighner, D.L. Hreniuk, R.G. Smith, A.D. Howard, L.H. Van, Genomics 46, 426 (1997)PubMedCrossRefGoogle Scholar
  27. 27.
    B. Holst, N.D. Holliday, A. Bach, C.E. Elling, H.M. Cox, T.W. Schwartz, J. Biol. Chem. 279, 53806 (2004)PubMedCrossRefGoogle Scholar
  28. 28.
    J.V. Zhang, H. Jahr, C.W. Luo, C. Klein, K. Van Kolen, L. Ver Donck, A. De, E. Baart, J. Li, D. Moechars, A.J. Hsueh, Mol. Endocrinol. 22, 1464 (2008)PubMedCrossRefGoogle Scholar
  29. 29.
    V. Catalán, J. Gómez-Ambrosi, F. Rotellar, C. Silva, M.J. Gil, A. Rodríguez, J.A. Cienfuegos, J. Salvador, G. Frühbeck, Clin. Endocrinol. 66, 598 (2007)Google Scholar
  30. 30.
    V.R. Jackson, H.P. Nothacker, O. Civelli, Neuroreport 29, 813 (2006)CrossRefGoogle Scholar
  31. 31.
    D. Moechars, I. Depoortere, B. Moreaux, B. de Smet, I. Goris, L. Hoskens, G. Daneels, S. Kass, L. Ver Donck, T. Peeters, B. Coulie, Gastroenterology 131, 1131 (2006)PubMedCrossRefGoogle Scholar
  32. 32.
    B. Holst, K.L. Egerod, E. Schild, S.P. Vickers, S. Cheetham, L.O. Gerlach, L. Storjohann, C.E. Stidsen, R. Jones, A.G. Beck-Sickinger, T.W. Schwartz, Endocrinology 148, 13 (2007)PubMedCrossRefGoogle Scholar
  33. 33.
    E. Lauwers, B. Landuyt, L. Arckens, L. Schoofs, W. Luyten, Biochem. Biophys. Res. Commun. 351, 21 (2006)PubMedCrossRefGoogle Scholar
  34. 34.
    R. Nogueiras, P. Pfluger, S. Tovar, M. Arnold, S. Mitchell, A. Morris, D. Perez-Tilve, M.J. Vázquez, P. Wiedmer, T.R. Castañeda, R. DiMarchi, M. Tschöp, A. Schurmann, H.G. Joost, L.M. Williams, W. Langhans, C. Diéguez, Endocrinology 148, 21 (2007)PubMedCrossRefGoogle Scholar
  35. 35.
    N. Chartrel, R. Alvear-Perez, J. Leprince, X. Iturrioz, A. Reaux-Le Goazigo, V. Audinot, P. Chomarat, F. Coge, O. Nosjean, M. Rodriguez, J.P. Galizzi, J.A. Boutin, H. Vaudry, C. Llorens-Cortes, Comment on “Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin’s effects on food intake”. Science 315, 766 (2007)Google Scholar
  36. 36.
    R. Granata, F. Settanni, D. Gallo, L. Trovato, L. Biancone, V. Cantaluppi, R. Nano, M. Annunziata, P. Campiglia, E. Arnoletti, C. Ghè, M. Volante, M. Papotti, G. Muccioli, E. Ghigo, Diabetes 57, 967 (2008)PubMedCrossRefGoogle Scholar
  37. 37.
    S. Unniappan, M. Speck, T.J. Kieffer, Peptides 29, 1354 (2008)PubMedCrossRefGoogle Scholar
  38. 38.
    R. Granata, M. Volante, F. Settanni, C. Gauna, C. Ghé, M. Annunziata, B. Deidda, I. Gesmundo, T. Abribat, A. Van der Lely, G. Muccioli, E. Ghigo, M. Papotti, J. Mol. Endocrinol. 45, 9 (2010)PubMedCrossRefGoogle Scholar
  39. 39.
    M. Kapica, M. Zabielska, I. Puzio, A. Jankowska, I. Kato, A. Kuwahara, R. Zabielski, J. Physiol. Pharmacol. 58(Suppl. 3), 123 (2007)PubMedGoogle Scholar
  40. 40.
    M. Kapica, I. Puzio, I. Kato, A. Kuwahara, R. Zabielski, J. Physiol. Pharmacol. 59(Suppl. 2), 145 (2008)PubMedGoogle Scholar
  41. 41.
    S.S. Qader, R. Håkanson, J.F. Rehfeld, I. Lundquist, A. Salehi, Regul. Pept. 146, 230 (2008)PubMedCrossRefGoogle Scholar
  42. 42.
    A.J. Ren, Z.F. Guo, Y.K. Wang, L.G. Wang, W.Z. Wang, L. Lin, X. Zheng, W.J. Yuan, Biochem. Biophys. Res. Commun. 369, 969 (2008)PubMedCrossRefGoogle Scholar
  43. 43.
    B.D. Green, N. Irwin, P.R. Flatt, Peptides 28, 981 (2007)PubMedCrossRefGoogle Scholar
  44. 44.
    E.M. Egido, R. Hernández, J. Marco, R.A. Silvestre, Regul. Pept. 152, 61 (2009)PubMedCrossRefGoogle Scholar
  45. 45.
    R.M. Kiewiet, C. Gauna, M.O. van Aken, B. van de Zande, A.J. van der Lely, Peptides 29, 2144 (2008)PubMedCrossRefGoogle Scholar
  46. 46.
    D. Yamamoto, N. Ikeshita, R. Daito, E.H. Herningtyas, K. Toda, K. Takahashi, K. Iida, Y. Takahashi, H. Kaji, K. Chihara, Y. Okimura, Regul. Pept. 138, 141 (2007)PubMedCrossRefGoogle Scholar
  47. 47.
    T. Nakahara, T. Harada, D. Yasuhara, N. Shimada, H. Amitani, T. Sakoguchi, M.M. Kamiji, A. Asakawa, A. Inui, Biol. Psychiatry 64, 252 (2008)PubMedCrossRefGoogle Scholar
  48. 48.
    K. Zwirska-Korczala, S.J. Konturek, M. Sodowski, M. Wylezol, D. Kuka, P. Sowa, M. Adamczyk-Sowa, M. Kukla, A. Berdowska, J.F. Rehfeld, W. Bielanski, T. Brzozowski, J. Physiol. Pharmacol. 58, 13 (2007)PubMedGoogle Scholar
  49. 49.
    P.B. Balagopal, S.S. Gidding, L.M. Buckloh, H.N. Yarandi, J.E. Sylvester, D.E. George, V.L. Funanage, Changes in circulating satiety hormones in obese children: A randomized controlled physical activity-based intervention study. Obesity (Silver Spring). 2010 Jan 21 [Epub ahead of print]Google Scholar
  50. 50.
    Z.F. Guo, X. Zheng, Y.W. Qin, J.Q. Hu, S.P. Chen, Z. Zhang, J. Clin. Endocrinol. Metab. 92, 1875 (2007)PubMedCrossRefGoogle Scholar
  51. 51.
    X.Y. Gao, H.Y. Kuang, X.M. Liu, Z.B. Ma, Peptides 31, 291 (2010)PubMedCrossRefGoogle Scholar
  52. 52.
    V. Vicennati, S. Genghini, R. De Iasio, F. Pasqui, U. Pagotto, R. Pasquali, Eur. J. Endocrinol. 157, 295 (2007)PubMedCrossRefGoogle Scholar
  53. 53.
    X. Qi, L. Li, G. Yang, J. Liu, K. Li, Y. Tang, H. Liou, G. Boden, Clin. Endocrinol. (Oxf). 66, 593 (2007)Google Scholar
  54. 54.
    M. Anderwald-Stadler, M. Krebs, M. Promintzer, M. Mandl, M.G. Bischof, P. Nowotny, T. Kästenbauer, A. Luger, R. Prager, C. Anderwald, Am. J. Physiol. Endocrinol. Metab. 293, E1393 (2007)PubMedCrossRefGoogle Scholar
  55. 55.
    X.Y. Gao, H.Y. Kuang, X.M. Liu, Z.B. Ma, H.J. Nie, H. Guo, Peptides 29, 1749 (2008)PubMedCrossRefGoogle Scholar
  56. 56.
    E. Alexandridis, A. Zisimopoulos, N. Liratzopoulos, I. Katsos, K. Manolas, G. Kouklakis, Inflamm. Bowel. Dis. 15, 1557 (2009)PubMedCrossRefGoogle Scholar
  57. 57.
    M.M. Alnema, S. Aydin, Y. Ozkan, A.F. Dagli, H.I. Ozercan, N. Yildirim, I. Sahin, A. Karaoglu, N. Kilic, M. Yilmaz, M.R. Ozercan, E. Donder, Mol. Cell. Biochem. 339, 173 (2010)PubMedCrossRefGoogle Scholar
  58. 58.
    T. Harada, T. Nakahara, D. Yasuhara, S. Kojima, K. Sagiyama, H. Amitani, A. Laviano, T. Naruo, A. Inui, Biol. Psychiatry 63, 245 (2008)PubMedCrossRefGoogle Scholar
  59. 59.
    N. Germain, B. Galusca, D. Grouselle, D. Frere, S. Billard, J. Epelbaum, B. Estour, J. Clin. Endocrinol. Metab. 95, 3057 (2010)PubMedCrossRefGoogle Scholar
  60. 60.
    Y. Gutierrez-Grobe, I. Villalobos-Blasquez, K. Sánchez-Lara, A.R. Villa, G. Ponciano-Rodríguez, M.H. Ramos, N.C. Chavez-Tapia, M. Uribe, N. Méndez-Sánchez, Ann. Hepatol. 9, 52 (2010)PubMedGoogle Scholar
  61. 61.
    N. Nagaya, M. Kojima, M. Uematsu, M. Yamagishi, H. Hosoda, H. Oya, Y. Hayashi, K. Kangawa, Am. J. Physiol. Regul. Integr. Comp. Physiol. 280, R1483 (2001)PubMedGoogle Scholar
  62. 62.
    N. Nagaya, K. Miyatake, M. Uematsu, H. Oya, W. Shimizu, H. Hosoda, M. Kojima, N. Nakanishi, H. Mori, K. Kangawa, J. Clin. Endocrinol. Metab. 86, 5854 (2001)PubMedCrossRefGoogle Scholar
  63. 63.
    Z.F. Li, Z.F. Guo, J. Cao, J.Q. Hu, X.X. Zhao, R.L. Xu, X.M. Huang, Y.W. Qin, X. Zheng, Peptides 31, 297 (2010)PubMedCrossRefGoogle Scholar
  64. 64.
    A.J. Ren, Q. He, J.S. Shi, Z.F. Guo, X. Zheng, L. Lin, Y.K. Wang, S.Y. Xia, L.L. Sun, X. Du, Y. Sun, L.M. Zhang, W.J. Yuan, Peptides 30, 1742 (2009)PubMedCrossRefGoogle Scholar
  65. 65.
    E. Kellokoski, A. Kunnari, M. Jokela, S. Mäkelä, Y.A. Kesäniemi, S. Hörkkö, Metabolism 58, 1572 (2009)PubMedCrossRefGoogle Scholar
  66. 66.
    M.J. Iglesias, A. Salgado, R. Piñeiro, B.K. Rodiño, M.F. Otero, L. Grigorian, R. Gallego, C. Diéguez, O. Gualillo, J.R. González-Juanatey, F. Lago, J. Endocrinol. Invest. 30, 470 (2007)PubMedGoogle Scholar
  67. 67.
    Z.F. Li, S.W. Song, Y.W. Qin, J.L. Zhang, X.X. Zhao, B.L. Zhang, A.J. Ren, Z.F. Guo, X. Zheng, Peptides 30, 1928 (2009)PubMedCrossRefGoogle Scholar
  68. 68.
    E. Szentirmai, J.M. Krueger, Neurosci. Lett. 404, 222 (2006)PubMedCrossRefGoogle Scholar
  69. 69.
    V.P. Carlini, M.M. Varas, A.B. Cragnolini, Biochem. Biophys. Res. Commun. 313, 635 (2004)PubMedCrossRefGoogle Scholar
  70. 70.
    V.P. Carlini, H.B. Schioth, S.R. Debarioglio, Biochem. Biophys. Res. Commun. 352, 907 (2007)PubMedCrossRefGoogle Scholar
  71. 71.
    E. Bresciani, D. Rapetti, F. Dona, I. Bulgarelli, L. Tamiazzo, V. Locatelli, A. Torsello, J. Endocrinol. Invest. 29, 16 (2006)Google Scholar
  72. 72.
    G.J. Lagaud, A. Young, A. Acena, M.F. Morton, T.D. Barrett, N.P. Shankley, Biochem. Biophys. Res. Commun. 357, 264 (2007)PubMedCrossRefGoogle Scholar
  73. 73.
    L. Brunetti, S. Leone, G. Orlando, L. Recinella, C. Ferrante, A. Chiavaroli, C. Di Nisio, P. Di Michele, M. Vacca, Peptides 30, 1323 (2009)PubMedCrossRefGoogle Scholar
  74. 74.
    G. Gourcerol, M. Million, D.W. Adelson, Y. Wang, L. Wang, J. Rivier, D.H. St-Pierre, Y. Taché, Peptides 27, 2811 (2006)PubMedCrossRefGoogle Scholar
  75. 75.
    P. Kobelt, A.S. Wisser, A. Stengel, M. Goebel, N. Bannert, G. Gourcerol, T. Inhoff, S. Noetzel, B. Wiedenmann, B.F. Klapp, Y. Taché, H. Mönnikes, Peptides 29, 1018 (2008)PubMedCrossRefGoogle Scholar
  76. 76.
    V.D. Annemie, V.D. Debby, V. Valentijn, S. de Bart, L. Walter, S. Liliane, D. de Peter Paul, Regul. Pept. 156, 77 (2009)PubMedCrossRefGoogle Scholar
  77. 77.
    W.K. Samson, M.M. White, C. Price, A.V. Ferguson, Am. J. Physiol. Regul. Integr. Comp. Physiol. 292, 637 (2007)CrossRefGoogle Scholar
  78. 78.
    W.K. Samson, G.L. Yosten, J.K. Chang, A.V. Ferguson, M.M. White, J. Endocrinol. 196, 559 (2008)PubMedCrossRefGoogle Scholar
  79. 79.
    K. Ataka, A. Inui, A. Asakawa, I. Kato, M. Fujimiya, Am. J. Physiol. Gastrointest. Liver Physiol. 294, 1210 (2008)CrossRefGoogle Scholar
  80. 80.
    M. Fujimiya, A. Asakawa, K. Ataka, I. Kato, A. Inui, World J. Gastroenterol. 14, 6318 (2008)PubMedCrossRefGoogle Scholar
  81. 81.
    C.Y. Chen, M.L. Doong, C.P. Li, W.J. Liaw, H.F. Lee, F.Y. Chang, H.C. Lin, S.D. Lee, Peptides 31, 1113 (2010)PubMedCrossRefGoogle Scholar
  82. 82.
    G. Gourcerol, T. Coskun, L.S. Craft, J.P. Mayer, M.L. Heiman, L. Wang, M. Million, D.H. St-Pierre, Y. Taché, Obesity (Silver Spring) 15, 2643 (2007)CrossRefGoogle Scholar
  83. 83.
    I. Depoortere, T. Thijs, D. Moechars, B. De Smet, L. Ver Donck, T.L. Peeters, Br. J. Pharmacol. 153, 1550 (2008)PubMedCrossRefGoogle Scholar
  84. 84.
    B.D. Spiegeleer, V. Vergotte, A. Pezeshki, K. Peremans, C. Burvenich, Anal. Biochem. 376, 229 (2008)PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Jiang-Bo Li
    • 1
  • Akihiro Asakawa
    • 1
  • KaiChun Cheng
    • 1
  • Yingxiao Li
    • 1
  • Huhe Chaolu
    • 1
  • Minglun Tsai
    • 1
  • Akio Inui
    • 1
  1. 1.Division of Psychosomatic Internal Medicine, Department of Social and Behavioral MedicineKagoshima University Graduate School of Medical and Dental SciencesKagoshimaJapan

Personalised recommendations