, Volume 37, Issue 2, pp 312–321 | Cite as

Epithelial progenitor 1, a novel factor associated with epithelial cell growth and differentiation

  • Marcie R. Kritzik
  • Cory U. Lago
  • Ayse G. Kayali
  • Sandrine Arnaud-Dabernat
  • Guoxun Liu
  • You-Qing Zhang
  • Hong Hua
  • Howard S. Fox
  • Nora E. Sarvetnick
Original Article


The growth and renewal of epithelial tissue is a highly orchestrated and tightly regulated process occurring in different tissue types under a variety of circumstances. We have been studying the process of pancreatic regeneration in mice. We have identified a cell surface protein, named EP1, which is expressed on the duct epithelium during pancreatic regeneration. Whereas it is not detected in the pancreas of normal mice, it is found in the intestinal epithelium of normal adult mice, as well as during pancreatic repair following cerulein-induced destruction of the acinar tissue. The distinctive situations in which EP1 is expressed, all of which share in common epithelial cell growth in the gastrointestinal tract, suggest that EP1 is involved in the growth and renewal of epithelial tissues in both the intestine and the pancreas.


Pancreas Intestine Regeneration SDF1 CXCR4 



Non-obese diabetic


Severe combined immunodeficiency


Fluorescence activated cell sorting


Leukocyte common antigen


Stromal-derived-factor-1 alpha


Chemokine (C-X-C motif) receptor 4








Lymphocyte antigen 6


Urokinase-type plasminogen activator receptor


Ly-6 antigen/uPA receptor-like domain


Phospholipase A2



We would like to thank Zhong Chen for his excellent technical contributions to this study. We would like to thank the members of the Sarvetnick lab for their helpful comments during the preparation of this article. We would like to thank Dr. Jason Cyster, UCSF, for giving us the SDF1a transgenic mice. This study was supported by grant DK 60746, awarded to Nora Sarvetnick by the National Institute of Health. MRK was funded by an Advanced Postdoctoral Fellowship from the JDRF; SAD was funded by an ACSBI fellowship of the International Union Against Cancer (UICC); YQZ was supported by a fellowship from NIH training grant T32 HL00795 and a career development award from the Crohn’s and Colitis Foundation of America and HH was supported by a fellowship from the Larry L. Hillblom Foundation. This manuscript number 18816 from The Scripps Research Institute.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Marcie R. Kritzik
    • 1
    • 4
  • Cory U. Lago
    • 1
    • 5
  • Ayse G. Kayali
    • 1
    • 6
  • Sandrine Arnaud-Dabernat
    • 1
    • 7
  • Guoxun Liu
    • 1
    • 8
  • You-Qing Zhang
    • 1
  • Hong Hua
    • 1
    • 9
  • Howard S. Fox
    • 2
    • 3
  • Nora E. Sarvetnick
    • 1
    • 4
  1. 1.Department of ImmunologyThe Scripps Research InstituteLa JollaUSA
  2. 2.Molecular and Integrative Neuroscience DepartmentThe Scripps Research InstituteLa JollaUSA
  3. 3.Department of Pharmacology and Experimental NeuroscienceLeid Transplant Center, University of Nebraska Medical CenterOmahaUSA
  4. 4.Department of SurgeryLeid Transplant Center, University of Nebraska Medical CenterOmahaUSA
  5. 5.Translational Medicine Branch, National HeartLung, and Blood Institute, National Institutes of HealthBethesdaUSA
  6. 6.The Islet Research Laboratory, Whittier Institute for Diabetes, Department of PediatricsSchool of Medicine, University of California San DiegoLa JollaUSA
  7. 7.Laboratoire de la Biologie de la Differenciation et du DeveloppementUniversity Victor SegalenBordeaux cedexFrance
  8. 8.Genomic Institute of the Novartis Research FoundationSan DiegoUSA
  9. 9.Johnson and Johnson PRDSInternal MedicineSan DiegoUSA

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