Epithelial progenitor 1, a novel factor associated with epithelial cell growth and differentiation
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The growth and renewal of epithelial tissue is a highly orchestrated and tightly regulated process occurring in different tissue types under a variety of circumstances. We have been studying the process of pancreatic regeneration in mice. We have identified a cell surface protein, named EP1, which is expressed on the duct epithelium during pancreatic regeneration. Whereas it is not detected in the pancreas of normal mice, it is found in the intestinal epithelium of normal adult mice, as well as during pancreatic repair following cerulein-induced destruction of the acinar tissue. The distinctive situations in which EP1 is expressed, all of which share in common epithelial cell growth in the gastrointestinal tract, suggest that EP1 is involved in the growth and renewal of epithelial tissues in both the intestine and the pancreas.
KeywordsPancreas Intestine Regeneration SDF1 CXCR4
Severe combined immunodeficiency
Fluorescence activated cell sorting
Leukocyte common antigen
Chemokine (C-X-C motif) receptor 4
Lymphocyte antigen 6
Urokinase-type plasminogen activator receptor
Ly-6 antigen/uPA receptor-like domain
We would like to thank Zhong Chen for his excellent technical contributions to this study. We would like to thank the members of the Sarvetnick lab for their helpful comments during the preparation of this article. We would like to thank Dr. Jason Cyster, UCSF, for giving us the SDF1a transgenic mice. This study was supported by grant DK 60746, awarded to Nora Sarvetnick by the National Institute of Health. MRK was funded by an Advanced Postdoctoral Fellowship from the JDRF; SAD was funded by an ACSBI fellowship of the International Union Against Cancer (UICC); YQZ was supported by a fellowship from NIH training grant T32 HL00795 and a career development award from the Crohn’s and Colitis Foundation of America and HH was supported by a fellowship from the Larry L. Hillblom Foundation. This manuscript number 18816 from The Scripps Research Institute.
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