Endocrine

, Volume 37, Issue 1, pp 33–39

Allergic reactions to human insulin: a review of current knowledge and treatment options

  • Baris Akinci
  • Serkan Yener
  • Firat Bayraktar
  • Sena Yesil
Review

Abstract

Although the incidence of insulin allergy decreased after the introduction of recombinant human insulin preparations, it is still a major problem which may be life-threatening in some cases. In this article, we attempted to review current knowledge concerning allergic reactions to human insulin and discuss the available treatment options of insulin allergy.

Keywords

Allergic reactions Diabetes Insulin treatment 

References

  1. 1.
    L. Fernandez, S. Duque, C. Montalban, B. Bartolome, Allergy 58, 1317 (2003)CrossRefPubMedGoogle Scholar
  2. 2.
    C. Blanco, R. Castillo, J. Quiralte, J. Delgado, I. Garcia, P. de Pablos, T. Carrillo, Allergy 51, 421–424 (1996)PubMedGoogle Scholar
  3. 3.
    L. Heinzerling, K. Raile, H. Rochlitz, T. Zuberbier, M. Worm, Allergy 63, 148–155 (2008)CrossRefPubMedGoogle Scholar
  4. 4.
    T. Mandrup-Poulsen, J. Molvig, J. Pildal, A.A. Rasmussen, L. Andersen, B.G. Skov, J. Petersen, Diabetes Care 25, 242–243 (2002)CrossRefPubMedGoogle Scholar
  5. 5.
    R. Wessbecher, M. Kiehn, E. Stoffel, I. Moll, Allergy 56, 919–920 (2001)CrossRefPubMedGoogle Scholar
  6. 6.
    R.P. Radermecker, A.J. Scheen, Diabetes Metab. Res. Rev. 23, 348–355 (2007)CrossRefPubMedGoogle Scholar
  7. 7.
    G. Schernthaner, Diabetes Care 16(Suppl 3), 155–165 (1993)PubMedGoogle Scholar
  8. 8.
    P. Darmon, V. Castera, M.C. Koeppel, C. Petitjean, A. Dutour, Diabetes Care 28, 2980 (2005)CrossRefPubMedGoogle Scholar
  9. 9.
    M.E. Silva, M.J. Mendes, M.J. Ursich, D.M. Rocha, A.H. Brito, R.T. Fukui, G.B. Ruggeri, M. Nery, B.L. Wajchenberg, Diabetes Res. Clin. Pract. 36, 67–70 (1997)CrossRefPubMedGoogle Scholar
  10. 10.
    R.D. de Shazo, T.M. Boehm, D. Kumar, J.A. Galloway, H.F. Dvorak, J. Allergy Clin. Immunol. 69, 229–237 (1982)CrossRefGoogle Scholar
  11. 11.
    H.G. Velcovsky, K.F. Federlin, Diabetes Care 5(Suppl 2), 126–128 (1982)PubMedGoogle Scholar
  12. 12.
    U. Bodtger, M. Wittrup, Diabet. Med. 22, 102–106 (2005)CrossRefPubMedGoogle Scholar
  13. 13.
    R.S. Gruchalla, Curr. Opin. Allergy Clin. Immunol. 2, 295–296 (2002)CrossRefPubMedGoogle Scholar
  14. 14.
    R. Patterson, M. Roberts, L.C. Grammer, Ann. Allergy 64, 459–462 (1990)PubMedGoogle Scholar
  15. 15.
    M. Katahira, I. Hara, T. Nishizaki, Diabet. Med. 22, 1455–1457 (2005)CrossRefPubMedGoogle Scholar
  16. 16.
    M.E. Bollinger, R.G. Hamilton, R.A. Wood, J. Allergy Clin. Immunol. 104, 462–465 (1999)CrossRefPubMedGoogle Scholar
  17. 17.
    D.F. Child, S.G. Johansson, Allergy 39, 630–633 (1984)CrossRefPubMedGoogle Scholar
  18. 18.
    L.A. Witters, J.L. Ohman, G.C. Weir, L.W. Raymond, F.C. Lowell, Am. J. Med. 63, 703–709 (1977)CrossRefPubMedGoogle Scholar
  19. 19.
    A.Y. Lee, W.Y. Chey, J. Choi, J.S. Jeon, Acta Derm. Venereol. 82, 114–117 (2002)CrossRefPubMedGoogle Scholar
  20. 20.
    L. Grammer, Clin. Rev. Allergy 4, 189–200 (1986)PubMedGoogle Scholar
  21. 21.
    A. Adachi, A. Fukunaga, T. Horikawa, Int. J. Dermatol. 43, 597–599 (2004)CrossRefPubMedGoogle Scholar
  22. 22.
    H. Nishi, S. Nishimura, M. Higashiura, N. Ikeya, H. Ohta, T. Tsuji, M. Nishimura, S. Ohnishi, H. Higashi, J. Immunol. Methods 240, 39–46 (2000)CrossRefPubMedGoogle Scholar
  23. 23.
    M. Maislos, P.M. Mead, D.H. Gaynor, D.C. Robbins, J. Clin. Invest. 77, 717–723 (1986)CrossRefPubMedGoogle Scholar
  24. 24.
    V. Castera, A. Dutour-Meyer, M. Koeppel, C. Petitjean, P. Darmon, Diabetes Metab. 31, 391–400 (2005)CrossRefPubMedGoogle Scholar
  25. 25.
    J.A. Loeb, K.C. Herold, K.P. Barton, L.E. Robinson, J.B. Jaspan, Diabetes Care 12, 421–423 (1989)CrossRefPubMedGoogle Scholar
  26. 26.
    W. Grant, R.D. de Shazo, J. Frentz, Diabetes Care 9, 318–319 (1986)PubMedGoogle Scholar
  27. 27.
    H. Yokoyama, S. Fukumoto, H. Koyama, M. Emoto, Y. Kitagawa, Y. Nishizawa, Diabetes Res. Clin. Pract. 61, 161–166 (2003)CrossRefPubMedGoogle Scholar
  28. 28.
    H.H. Chng, K.P. Leong, K.C. Loh, Allergy 50, 984–987 (1995)CrossRefPubMedGoogle Scholar
  29. 29.
    V. Matheu, E. Perez, M. Hernandez, E. Diaz, R. Darias, A. Gonzalez, J.C. Garcia, I. Sanchez, L. Feliciano, A. Caballero et al., Clin. Mol. Allergy 3, 16 (2005)CrossRefPubMedGoogle Scholar
  30. 30.
    C. Frigerio, M. Aubry, F. Gomez, L. Graf, E. Dayer, N. de Kalbermatten, R.C. Gaillard, F. Spertini, Allergy 52, 238–239 (1997)CrossRefPubMedGoogle Scholar
  31. 31.
    M. Asai, M. Yoshida, Y. Miura, N. Engl. J. Med. 354, 307–309 (2006)CrossRefPubMedGoogle Scholar
  32. 32.
    K.A. Neville, C.F. Verge, B.K. Wainstein, H.J. Woodhead, J.B. Ziegler, J.L. Walker, Pediatr. Diabetes 9, 420–422 (2008)CrossRefPubMedGoogle Scholar
  33. 33.
    N.S. Fineberg, S.E. Fineberg, J.H. Anderson, M.A. Birkett, R.G. Gibson, S. Hufferd, Diabetes 45, 1750–1754 (1996)CrossRefPubMedGoogle Scholar
  34. 34.
    A. Lindholm, L.B. Jensen, P.D. Home, P. Raskin, B.O. Boehm, J. Rastam, Diabetes Care 25, 876–882 (2002)CrossRefPubMedGoogle Scholar
  35. 35.
    X. JiXiong, L. Jianying, C. Yulan, C. Huixian, Diabetes Care 27, 2084–2085 (2004)CrossRefPubMedGoogle Scholar
  36. 36.
    R. Barranco, T. Herrero, P. Tornero, M. Barrio, C. Frutos, A. Rodriguez, V. Malvetti, M. Luisa Baeza, Allergy 58, 536–537 (2003)CrossRefPubMedGoogle Scholar
  37. 37.
    S. Mizuhashi, K. Nakamura, Y. Mori, M. Noda, K. Nakanishi, Diabetes Care 29, 1711–1712 (2006)CrossRefPubMedGoogle Scholar
  38. 38.
    R.E. Ratner, T.M. Phillips, M. Steiner, Diabetes 39, 728–733 (1990)CrossRefPubMedGoogle Scholar
  39. 39.
    I.B. Hirsch, N. Engl. J. Med. 352, 174–183 (2005)CrossRefPubMedGoogle Scholar
  40. 40.
    D. Kumar, Diabetes Care 20, 1357–1359 (1997)CrossRefPubMedGoogle Scholar
  41. 41.
    M.R. Abraham, B.A. al-Sharafi, G.A. Saavedra, R. Khardori, Diabetes Care 22, 1916–1917 (1999)CrossRefPubMedGoogle Scholar
  42. 42.
    M. Lluch-Bernal, M. Fernandez, J.L. Herrera-Pombo, J. Sastre, Allergy 54, 186–187 (1999)CrossRefPubMedGoogle Scholar
  43. 43.
    P. Panczel, N. Hosszufalusi, M.M. Horvath, A. Horvath, Allergy 55, 409–410 (2000)CrossRefPubMedGoogle Scholar
  44. 44.
    S. Ghosh, V. McCann, L. Bartle, A. Collier, I. Malik, Diabet. Med. 24, 1307 (2007)CrossRefPubMedGoogle Scholar
  45. 45.
    I.R. Blumer, Diabetes Care 29, 946 (2006)CrossRefPubMedGoogle Scholar
  46. 46.
    M.A. Mollar-Puchades, I.L. Villanueva, Diabetes Res. Clin. Pract. 83, e21–e22 (2009)CrossRefPubMedGoogle Scholar
  47. 47.
    H. Takata, Y. Kumon, F. Osaki, C. Kumagai, K. Arii, Y. Ikeda, T. Suehiro, K. Hashimoto, Diabetes Care 26, 253–254 (2003)CrossRefPubMedGoogle Scholar
  48. 48.
    H. Moriyama, M. Nagata, K. Fujihira, K. Yamada, S.A. Chowdhury, S. Chakrabarty, Z. Jin, H. Yasuda, H. Ueda, K. Yokono, Diabetes Care 24, 411–412 (2001)CrossRefPubMedGoogle Scholar
  49. 49.
    C. Kara, A.O. Kutlu, O. Evliyaoglu, H. Bilgili, N. Yildirim, Diabetes Care 28, 983–984 (2005)CrossRefPubMedGoogle Scholar
  50. 50.
    C. Pfohler, C.S. Muller, D.O. Hasselmann, W. Tilgen, J. Med. Case Reports 2, 283 (2008)CrossRefPubMedGoogle Scholar
  51. 51.
    M. Hara, Y. Izumida, N. Sato, K. Ohashi, J.I. Osuga, K. Tobe, K. Tsukamoto, T. Kadowaki, Diabetes Res. Clin. Pract. 84, 48–49 (2009)Google Scholar
  52. 52.
    K.N. Durand-Gonzalez, N. Guillausseau, C. Pecquet, J.P. Gayno, Diabetes Care 26, 2216 (2003)CrossRefPubMedGoogle Scholar
  53. 53.
    V. Moyes, R. Driver, A. Croom, R. Mirakian, T.A. Chowdhury, Diabet. Med. 23, 204–206 (2006)CrossRefPubMedGoogle Scholar
  54. 54.
    I. Blumer, Diabet. Med. 25, 1008 (2008)CrossRefPubMedGoogle Scholar
  55. 55.
    A. Sola-Gazagnes, C. Pecquet, J. M’Bemba, E. Larger, G. Slama, Lancet 369, 637–638 (2007)CrossRefPubMedGoogle Scholar
  56. 56.
    E. Perez, R. Gonzalez, J. Martinez, J. Iglesias, V. Matheu, Ann. Allergy Asthma Immunol. 102, 174–175 (2009)CrossRefPubMedGoogle Scholar
  57. 57.
    S.S. Eapen, E.L. Connor, J.E. Gern, Ann. Allergy Asthma Immunol. 85, 395–397 (2000)CrossRefPubMedGoogle Scholar
  58. 58.
    E.J. Pratt, P. Miles, D. Kerr, Diabet. Med. 18, 515–516 (2001)CrossRefPubMedGoogle Scholar
  59. 59.
    S. Naf, E. Esmatjes, M. Recasens, A. Valero, I. Halperin, I. Levy, R. Gomis, Diabetes Care 25, 634–635 (2002)CrossRefPubMedGoogle Scholar
  60. 60.
    A. Sola-Gazagnes, C. Pecquet, R. Radermecker, L. Pietri, F. Elgrably, G. Slama, J.L. Selam, Diabetes Care 26, 2961–2962 (2003)CrossRefPubMedGoogle Scholar
  61. 61.
    B.A. Geldof, A.P. Oranje, T. van Joost, Contact Dermatitis 20, 384–385 (1989)CrossRefPubMedGoogle Scholar
  62. 62.
    J. Beltrand, S. Guilmin-Crepon, M. Castanet, M. Peuchmaur, P. Czernichow, C. Levy-Marchal, Horm. Res. 65, 253–260 (2006)CrossRefPubMedGoogle Scholar
  63. 63.
    K.N. Durand-Gonzalez, N. Guillausseau, M.L. Anciaux, V. Hentschel, J.P. Gayno, Diabetes Metab. 29, 432–434 (2003)CrossRefPubMedGoogle Scholar
  64. 64.
    T. Richardson, D. Kerr, Am. J. Clin. Dermatol. 4, 661–667 (2003)CrossRefPubMedGoogle Scholar
  65. 65.
    J. Leonet, J. Malaise, E. Goffin, C. Lefebvre, D. Tennstedt, B. Vandeleene, M. Buysschaert, J.P. Squifflet, Transpl. Int. 19, 474–477 (2006)CrossRefPubMedGoogle Scholar
  66. 66.
    P.F. Yong, R. Malik, S. Arif, M. Peakman, S. Amiel, M.A. Ibrahim, A.N. Gough, Engl. J. Med. 360, 1045–1047 (2009)CrossRefGoogle Scholar
  67. 67.
    K.A. Page, S. Dejardin, C.R. Kahn, R.N. Kulkarni, K.C. Herold, S.E. Inzucchi, Nat. Clin. Pract. Endocrinol. Metab. 3, 835–840 (2007)CrossRefPubMedGoogle Scholar
  68. 68.
    E. Arioglu, A. Andewelt, C. Diabo, M. Bell, S.I. Taylor, P. Gorden, Medicine (Baltimore) 81, 87–100 (2002)CrossRefGoogle Scholar
  69. 69.
    J.W. Eriksson, T. Bremell, B. Eliasson, J. Fowelin, L. Fredriksson, Z.W. Yu, Diabetes Care 21, 1217–1220 (1998)CrossRefPubMedGoogle Scholar
  70. 70.
    K. Kawanishi, K. Kawamura, Y. Nishina, A. Goto, S.J. Okada, Clin. Endocrinol. Metab. 44, 15–21 (1977)CrossRefGoogle Scholar
  71. 71.
    A.P. Coll, S. Thomas, G.J. Mufti, N. Engl. J. Med. 350, 310–311 (2004)CrossRefPubMedGoogle Scholar
  72. 72.
    A. Gehi, A. Webb, M. Nolte, J. Davis Jr., Arthritis Rheum. 48, 1067–1070 (2003)CrossRefPubMedGoogle Scholar
  73. 73.
    Y. Kajimoto, R. Kawamori, Y. Fujitani, M. Kishimoto, M. Kubota, Y. Yamasaki, T. Morishima, T. Kamada, Endocr. J. 42, 101–105 (1995)CrossRefPubMedGoogle Scholar
  74. 74.
    B.C. McLeod, Best Pract. Res. Clin. Haematol. 19, 157–167 (2006)CrossRefPubMedGoogle Scholar
  75. 75.
    R. Koyama, K. Nakanishi, M. Kato, S. Yamashita, H. Kuwahara, H. Katori, Am. J. Med. Sci. 329, 259–264 (2005)CrossRefPubMedGoogle Scholar
  76. 76.
    F. Bayraktar, B. Akinci, F. Demirkan, S. Yener, S. Yesil, C. Kirmaz, A. Comlekci, Diabet. Med. 26, 659–660 (2009)CrossRefPubMedGoogle Scholar
  77. 77.
    H.K. Oh, R. Provenzano, J. Hendrix, M.W. el-Nachef, Clin. Transplant. 12, 593–595 (1998)PubMedGoogle Scholar
  78. 78.
    J. Malaise, J. Leonet, E. Goffin, C. Lefebvre, D. Tennstedt, B. Vandeleene, M. Buysschaert, J.P. Squifflet, Transplant. Proc. 37, 2839 (2005)CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Baris Akinci
    • 1
  • Serkan Yener
    • 1
  • Firat Bayraktar
    • 1
  • Sena Yesil
    • 1
  1. 1.Division of Endocrinology of Metabolism, Department of Internal MedicineDokuz Eylul University Medical SchoolIzmirTurkey

Personalised recommendations