Endocrine

, Volume 36, Issue 3, pp 425–432

A novel indicator of widespread endothelial damage and ischemia in diabetic patients: ischemia-modified albumin

  • Kubilay Ukinc
  • Selcuk Eminagaoglu
  • Halil Onder Ersoz
  • Cihangir Erem
  • Caner Karahan
  • Arif Bayram Hacihasanoglu
  • Mustafa Kocak
Original Article

DOI: 10.1007/s12020-009-9236-5

Cite this article as:
Ukinc, K., Eminagaoglu, S., Ersoz, H.O. et al. Endocr (2009) 36: 425. doi:10.1007/s12020-009-9236-5

Abstract

Ischemia-modified albumin (IMA) is a novel marker of tissue ischemia. Nowadays, IMA is accepted as a marker of oxidative stress. In this study, we aimed at establishing an association between IMA and hyperglycemia, blood pressure, lipid parameters, microvascular complications, hsCRP, and microalbuminuria in type 2 diabetes patients without overt macrovascular disease and acute ischemia. Fifty type 2 diabetes mellitus patients without a history of macrovascular disease or end-stage renal disease were enrolled into the study. Age-matched 30 healthy individuals were also included in the study as a control group. Plasma IMA (0.329 ± 0.046 and 0.265 ± 0.045 AbsU; P < 0.0001) and hsCRP levels (0.51 ± 0.36 and 0.32 ± 0.17 mg/dl; P < 0.0001) were significantly higher in the diabetic group compared to healthy controls. IMA level was significantly correlated with hsCRP (r = 0.76; P < 0.0001), HbA1c (r = 0.72; P < 0.0001), microalbuminuria (r = 0.40; P = 0.004), systolic blood pressure (r = 0.28; P = 0.049), diastolic blood pressure (r = 0.44; P = 0.005), and HOMA-IR (r = 0.42; P = 0.005) levels in the entire diabetic subjects. In the diabetic patients group, presence of microalbuminuria was associated with a higher plasma IMA level (0.355 ± 0.035 and 0.265 ± 0.0045 AbsU; P < 0.0001, patients with microalbuminuria and control subjects, respectively). In the type 2 diabetes patients with nephropathy, IMA level (0.355 ± 0.035 and 0.311 ± 0.046 AbsU; P = 0.002) was determined higher compared to the diabetes patients without nephropathy. Diabetic patients without an overt cardiovascular disease still have a higher serum IMA level compared to healthy controls. The correlation of high plasma IMA levels with high hsCRP and microalbuminuria levels in diabetic subjects indicates the presence of a chronic ischemic process. Therefore, elevated IMA levels may indicate an underlying subclinical vascular disease in type 2 diabetes mellitus patients.

Keywords

Ischemia-modified albumin Type 2 diabetes hsCRP Microvascular complications Diabetic nephropathy 

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Kubilay Ukinc
    • 1
  • Selcuk Eminagaoglu
    • 2
  • Halil Onder Ersoz
    • 3
  • Cihangir Erem
    • 3
  • Caner Karahan
    • 2
  • Arif Bayram Hacihasanoglu
    • 3
  • Mustafa Kocak
    • 3
  1. 1.Canakkale Onsekiz Mart Universitesi, Tip FakultesiEndokrinoloji ve Metabolizma Hastaliklari BDÇanakkaleTurkey
  2. 2.Department of BiochemistryKaradeniz Technical UniversityTrabzonTurkey
  3. 3.Department of Endocrinology and MetabolismKaradeniz Technical UniversityTrabzonTurkey

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