Endocrine

, Volume 35, Issue 3, pp 371–379

Circulating adiponectin represents a biomarker of the association between adiposity and bone mineral density

  • Kemal Ağbaht
  • Alper Gürlek
  • Jale Karakaya
  • Miyase Bayraktar
Original Paper

DOI: 10.1007/s12020-009-9158-2

Cite this article as:
Ağbaht, K., Gürlek, A., Karakaya, J. et al. Endocr (2009) 35: 371. doi:10.1007/s12020-009-9158-2

Abstract

An association exists between adiposity, insulin resistance, and osteoporosis; however, the mechanism of this relationship remains enigmatic. We aimed to determine whether the insulin resistance index (HOMA-IR), serum adiponectin, or leptin levels are associated with bone mineral density (BMD). A cross-sectional, observational study was designed. Eighty-four postmenopausal ambulant women [52.5 (50.0–58.0) years; body mass index (BMI): 29.4 (25.9–33.8) kg/m2] referred for osteoporosis screening were enrolled. Anthropometric measures, fasting serum adiponectin and leptin levels, and the HOMA-IR were determined. The relationships between these variables and lumbar, hip, and forearm BMD measured by dual-energy X-ray absorptiometry (DXA) were analyzed. Considering all 84 participants, the HOMA-IR index was 1.82 (1.17–2.86), serum adiponectin was 13.25 (10.49–16.88) μg/ml, and serum leptin was 19.26 (14.94–24.90) ng/ml. BMI, waist circumference, and leptin positively correlated with hip and lumbar BMD, whereas adiponectin negatively correlated. Multivariate analysis confirmed an inverse relation between serum adiponectin level and femoral neck and lumbar BMD measurements. In total hip and forearm areas, there was no independent association of adipocytokines with BMD measurements. Instead, waist circumference was independently associated with BMD measurements. In conclusion, adiponectin may represent a biomarker in the relationship between visceral fat mass and BMD. However, this association is probably confounded by the specific body composition parameters (i.e., waist circumference, BMI) in postmenopausal women.

Keywords

Adiposity HOMA-IR index Leptin Adiponectin Bone mineral density 

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Kemal Ağbaht
    • 1
  • Alper Gürlek
    • 2
  • Jale Karakaya
    • 3
  • Miyase Bayraktar
    • 2
  1. 1.Department of Internal Medicine, Endocrinology and Metabolism UnitAnkara University Faculty of MedicineAnkaraTurkey
  2. 2.Department of Internal Medicine, Endocrinology and Metabolism UnitHacettepe University Faculty of MedicineAnkaraTurkey
  3. 3.Department of BiostatisticsHacettepe University Faculty of MedicineAnkaraTurkey

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