, Volume 33, Issue 3, pp 300–304

Evaluation of the effect of caloric restriction on serum BDNF in overweight and obese subjects: preliminary evidences

  • A. Veronica Araya
  • Ximena Orellana
  • Jaime Espinoza
Original Paper

DOI: 10.1007/s12020-008-9090-x

Cite this article as:
Araya, A.V., Orellana, X. & Espinoza, J. Endocr (2008) 33: 300. doi:10.1007/s12020-008-9090-x


Brain-derived neurotrophic factor (BDNF) has emerged as a new element related with insulin resistance and obesity. Objective To evaluate the effect of a 3-month reduced-calorie diet (RCD) on serum BDNF concentrations in overweight and obese subjects. Subjects Seventeen healthy overweight and obese subjects of both sexes (24–48 years, BMI 34.6 ± 1.1 kg/m2). Methods Anthropometry, oral glucose tolerance test (OGTT), lipid levels, and serum BDNF were measured at baseline and at the end of the third month. Reduced-calorie diet was defined as a 25% reduction in energy intake composed of: 55% carbohydrates, 20% proteins, and 25% fat (less than 10% saturated fat and over 10% nonsaturated fat). Refined sugar was not allowed. Results There was a significant decrease in BMI, waist circumference, body fat percentage, fasting glucose, post-OGTT glucose levels, area under the curve of glucose, and HOMA2-IR after 3 months of RCD. Serum BDNF showed a significant increase (3.97 ± 0.87 to 6.75 ± 1.62 ng/ml, P = 0.02). Final serum BDNF correlated negatively with weight (r = −0.51, P = 0.03), and basal post-OGTT insulin correlated positively with final serum BDNF (r = 0.48, P = 0.04). Conclusions Serum BDNF increases in insulin-resistant overweight and obese subjects after three months on a RCD. This observation could indicate that BDNF may be modulated in humans through diet composition.


Serum BDNF Reduced-calorie diet Obesity Overweight 

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • A. Veronica Araya
    • 1
  • Ximena Orellana
    • 2
  • Jaime Espinoza
    • 3
  1. 1.Endocrinology Section, Department of Internal MedicineUniversity of Chile Clinical HospitalIndependencia, SantiagoChile
  2. 2.Nutrition SectionUniversity of Chile Clinical HospitalIndependencia, SantiagoChile
  3. 3.Laboratory of Endocrinology and Biology of ReproductionUniversity of Chile Clinical HospitalIndependencia, SantiagoChile

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