Comprehensive Therapy

, Volume 32, Issue 3, pp 158–162 | Cite as

Systemic lupus erythematosus Current state of diagnosis and treatment

Original Article


Systemic lupus erythematosus is a chronic autoimmune condition with a wide spectrum of clinical manifestations, characterized by the production of auto-antibodies to components of the cell nucleus. Treatments include various immunosuppressive regimens, and newer biological therapies show promising results.


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  1. 1.
    Petri M. Systemic lupus erythematosus. In: Clinical Primer of Rheumatology (Koopman WJ ed.) Lippincot Williams & Wilkins, Philadelphia. 2003, pp. 164–170.Google Scholar
  2. 2.
    Uramoto KM, Michet CJJ, Thumboo J, et al. Trends in the incidence and mortality of systemic lupus erythematosus, 1950–1992. Arthritis Rheum 1999;42:46–50.PubMedCrossRefGoogle Scholar
  3. 3.
    Selmi C, Lleo A, Zuin M, et al. Interferon alpha and its contribution to autoimmunity. Curr Opin Investig Drugs 2006;7:451–456.PubMedGoogle Scholar
  4. 4.
    Petri M, Kim MY, Kalunian KC, et al. Combined oral contraceptives in women with systemic lupus erythematosus. N Engl J Med 2005;353(24):2550–2558.PubMedCrossRefGoogle Scholar
  5. 5.
    Tan EM, Cohen AS, Fries JF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982;25:1271–1277.PubMedCrossRefGoogle Scholar
  6. 6.
    Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997;40:1725.PubMedCrossRefGoogle Scholar
  7. 7.
    Buyon J. Systemic lupus erythematosus. Clinical and laboratory features. In: Primer on the Rheumatic Diseases (Klippel JH ed.). Arthritis Foundation. Atlanta, 2001, pp. 335–346.Google Scholar
  8. 8.
    The Canadian Hydroxychoroquine Study Group. A randomized study effect of withdrawing hydroxychloroquine sulfate in systemic lupus erythematosus. N Engl J Med 1991;324:150–154.CrossRefGoogle Scholar
  9. 9.
    Tseng C, Buyon J, Belmont HM, et al. Moderate dose steroids prevent severe flares of serologically active, clinically stable SLE patients. Arthritis Rheum 2003;48:S260.Google Scholar
  10. 10.
    Houssiau FA, Vasconcelos C, D'Cruz D, et al. Immunosuppressive therapy in lupus nephritis. The Euro-Lupus Nephritis Trial, a randomized trial of low-dose versus high-dose intravenous cyclophosphamide. Arthritis Rheum 2002;46:2121–2131.PubMedCrossRefGoogle Scholar
  11. 11.
    Somers EC, Marder W, Christman GM, Ognenovski V, McCune WJ. Use of a gonadotropin-releasing hormone analog for protection against premature ovarian failure during cyclophosphamide therapy in women with severe lupus. Arthritis Rheum 2005;52:2761–2767.PubMedCrossRefGoogle Scholar
  12. 12.
    Ginzler EM, Dooley MA, Aranow C, et al. Mycophenolate mofetil or intravenous cyclophosphamide for lupus nephritis. N Engl J Med 2005;353:2219–2228.PubMedCrossRefGoogle Scholar
  13. 13.
    Contreras G, Pardo V, Leclercq B, et al. Sequential therapies for proliferative lupus nephritis. N Engl J Med 2004;350:971–980.PubMedCrossRefGoogle Scholar
  14. 14.
    Looney RJ, Anolik JH, Campbell D, et al. B cell depletion as a novel treatment for systemic lupus erythematosus: a phase I/II dose-escalation trial of rituximab. Arthritis Rheum 2004;50:2580–2589.PubMedCrossRefGoogle Scholar
  15. 15.
    Leandro MJ, Cambridge G, Edwards JC, Ehrenstein MR, Isenberg DA. B-cell depletion in the treatment of patients with systemic lupus erythematosus: a longitudinal analysis of 24 patients. Rheumatology (Oxford) 2005;44:1542–1545.CrossRefGoogle Scholar
  16. 16.
    Burt RK, Traynor A, Statkute L, et al. Nomyeloablative hematopoietic stem cell transplantation for systemic lupus erythematosus. JAMA 2006;295:527–535.PubMedCrossRefGoogle Scholar
  17. 17.
    Petri M, Jones RJ, Brodsky RA. High-dose cyclophosphamide without stem cell transplant in systemic lupus erythematosus. Arthritis Rheum 2003;48:166–173.PubMedCrossRefGoogle Scholar
  18. 18.
    Shakoor N, Michalska M, Harris CA, Block JA. Drug-induced systemic lupus erythematosus associated with etanercept therapy. Lancet 2002;359:579–580.PubMedCrossRefGoogle Scholar
  19. 19.
    Furie R, Stohl W, Ginzler E, et al. Safety, pharmacokinetics and pharmacodynamic results of a phase I single and double dose-escalation study of lymphostat B (human monoclonal antibody to BLyS) in SLE patients. Arthritis Rheum 2003;48:S377.Google Scholar
  20. 20.
    Alarcon-Segovia D, Tumlin AJ, Furie R, et al.: LJP 394 for the prevention of renal flare in patients with systemic lupus erythematosus. Arthritis Rheum 2003;48:442–454.PubMedCrossRefGoogle Scholar
  21. 21.
    Petri M, Mease PJ, Merrill JT, et al. Effects of prasterone on disease activity and symptoms in women with active systemic lupus erythematosus. Arthritis Rheum 2004;50:2858–2868.PubMedCrossRefGoogle Scholar
  22. 22.
    Mease PJ, Ginzler EM, Gluck OS, et al. Effects of prasterone on bone mineral density in women with systemic lupus erythematosus receiving chronic glucocorticoid therapy. J Rheumatol 2005;32(4):616–621.PubMedGoogle Scholar

Copyright information

© ASCMS 2006

Authors and Affiliations

  1. 1.Rheumatology DepartmentLoma Linda UniversityLoma Linda

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